New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217

Marylène Vandevenne, David A. Jacques, Crisbel Artuz, Cuong Dinh Nguyen, Ann H Y Kwan, David Segal, Jacqueline M. Matthews, Merlin Crossley, J. Mitchell Guss, Joel P. MacKay

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background: Classical zinc finger proteins are extremely abundant and interact with DNA using a well defined recognition code. Results: We solved the structure of ZNF217 bound to its cognate DNA. Conclusion: ZNF217 presents a unique DNA interaction pattern including a new type of protein-DNA contact. Significance: This study deepens our understanding of DNA recognition by classical zinc fingers.

Original languageEnglish (US)
Pages (from-to)10616-10627
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number15
DOIs
StatePublished - Apr 12 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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    Vandevenne, M., Jacques, D. A., Artuz, C., Nguyen, C. D., Kwan, A. H. Y., Segal, D., Matthews, J. M., Crossley, M., Guss, J. M., & MacKay, J. P. (2013). New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. Journal of Biological Chemistry, 288(15), 10616-10627. https://doi.org/10.1074/jbc.M112.441451