New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217

Marylène Vandevenne, David A. Jacques, Crisbel Artuz, Cuong Dinh Nguyen, Ann H Y Kwan, David Segal, Jacqueline M. Matthews, Merlin Crossley, J. Mitchell Guss, Joel P. MacKay

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Classical zinc finger proteins are extremely abundant and interact with DNA using a well defined recognition code. Results: We solved the structure of ZNF217 bound to its cognate DNA. Conclusion: ZNF217 presents a unique DNA interaction pattern including a new type of protein-DNA contact. Significance: This study deepens our understanding of DNA recognition by classical zinc fingers.

Original languageEnglish (US)
Pages (from-to)10616-10627
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number15
DOIs
StatePublished - Apr 12 2013

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Oncogene Proteins
Zinc Fingers
Structural analysis
Zinc
DNA
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Vandevenne, M., Jacques, D. A., Artuz, C., Nguyen, C. D., Kwan, A. H. Y., Segal, D., ... MacKay, J. P. (2013). New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. Journal of Biological Chemistry, 288(15), 10616-10627. https://doi.org/10.1074/jbc.M112.441451

New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. / Vandevenne, Marylène; Jacques, David A.; Artuz, Crisbel; Nguyen, Cuong Dinh; Kwan, Ann H Y; Segal, David; Matthews, Jacqueline M.; Crossley, Merlin; Guss, J. Mitchell; MacKay, Joel P.

In: Journal of Biological Chemistry, Vol. 288, No. 15, 12.04.2013, p. 10616-10627.

Research output: Contribution to journalArticle

Vandevenne, M, Jacques, DA, Artuz, C, Nguyen, CD, Kwan, AHY, Segal, D, Matthews, JM, Crossley, M, Guss, JM & MacKay, JP 2013, 'New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217', Journal of Biological Chemistry, vol. 288, no. 15, pp. 10616-10627. https://doi.org/10.1074/jbc.M112.441451
Vandevenne, Marylène ; Jacques, David A. ; Artuz, Crisbel ; Nguyen, Cuong Dinh ; Kwan, Ann H Y ; Segal, David ; Matthews, Jacqueline M. ; Crossley, Merlin ; Guss, J. Mitchell ; MacKay, Joel P. / New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 15. pp. 10616-10627.
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