New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217

Marylène Vandevenne; David A. Jacques; Crisbel Artuz; Cuong Dinh Nguyen; Ann H Y Kwan; David Segal; Jacqueline M. Matthews; Merlin Crossley; J. Mitchell Guss; Joel P. MacKay

doi:10.1074/jbc.M112.441451

New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217

Marylène Vandevenne, David A. Jacques, Crisbel Artuz, Cuong Dinh Nguyen, Ann H Y Kwan, David Segal, Jacqueline M. Matthews, Merlin Crossley, J. Mitchell Guss, Joel P. MacKay

Biochemistry and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background: Classical zinc finger proteins are extremely abundant and interact with DNA using a well defined recognition code. Results: We solved the structure of ZNF217 bound to its cognate DNA. Conclusion: ZNF217 presents a unique DNA interaction pattern including a new type of protein-DNA contact. Significance: This study deepens our understanding of DNA recognition by classical zinc fingers.

Original language	English (US)
Pages (from-to)	10616-10627
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	15
DOIs	https://doi.org/10.1074/jbc.M112.441451
State	Published - Apr 12 2013

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. / Vandevenne, Marylène; Jacques, David A.; Artuz, Crisbel; Nguyen, Cuong Dinh; Kwan, Ann H Y; Segal, David; Matthews, Jacqueline M.; Crossley, Merlin; Guss, J. Mitchell; MacKay, Joel P.

In: Journal of Biological Chemistry, Vol. 288, No. 15, 12.04.2013, p. 10616-10627.

Research output: Contribution to journal › Article › peer-review

Vandevenne, Marylène ; Jacques, David A. ; Artuz, Crisbel ; Nguyen, Cuong Dinh ; Kwan, Ann H Y ; Segal, David ; Matthews, Jacqueline M. ; Crossley, Merlin ; Guss, J. Mitchell ; MacKay, Joel P. / New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 15. pp. 10616-10627.

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AU - Segal, David

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AU - Guss, J. Mitchell

AU - MacKay, Joel P.

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