New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity

Stefania Recalcati, Pietro Invernizzi, Paolo Arosio, Gaetano Cairo

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Ferritin is a ubiquitous and specialised protein involved in the intracellular storage of iron; it is also present in serum and other biological fluids, although its secretion processes are still unclear. We here review evidence supporting the hypothesis that macrophages play a role in the production and secretion of extracellular ferritin, as well as evidence supporting a novel function as a signalling molecule and immune regulator. In particular, H-ferritin, which inhibits the proliferation of lymphoid and myeloid cells, may be regarded as a negative regulator of human and murine hematopoiesis. The idea that it also acts as a signalling protein has been supported by the cloning and characterisation of the specific H-ferritin receptor TIM-2, a member of the TIM gene family. A number of studies of the mouse TIM gene family indicate that this protein plays an important role in immune-mediated diseases. This last finding, together with the fact that ferritin acts as an immuno-suppressor, has allowed us to formulate hypotheses regarding the possible role of alterations of H-ferritin/TIM-2 binding/signalling in the pathogenesis of autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalJournal of Autoimmunity
Volume30
Issue number1-2
DOIs
StatePublished - Feb 2008

Fingerprint

Apoferritins
Ferritins
Autoimmunity
Immunity
Iron
Proteins
Secretory Pathway
Immune System Diseases
Hematopoiesis
Myeloid Cells
Genes
Autoimmune Diseases
Organism Cloning
Macrophages
Lymphocytes
Serum

Keywords

  • Autoimmune diseases
  • Ferritin
  • TIM gene family

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

New functions for an iron storage protein : The role of ferritin in immunity and autoimmunity. / Recalcati, Stefania; Invernizzi, Pietro; Arosio, Paolo; Cairo, Gaetano.

In: Journal of Autoimmunity, Vol. 30, No. 1-2, 02.2008, p. 84-89.

Research output: Contribution to journalArticle

Recalcati, Stefania ; Invernizzi, Pietro ; Arosio, Paolo ; Cairo, Gaetano. / New functions for an iron storage protein : The role of ferritin in immunity and autoimmunity. In: Journal of Autoimmunity. 2008 ; Vol. 30, No. 1-2. pp. 84-89.
@article{3b56162c6ddc4e53b74e97de6ebec1a0,
title = "New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity",
abstract = "Ferritin is a ubiquitous and specialised protein involved in the intracellular storage of iron; it is also present in serum and other biological fluids, although its secretion processes are still unclear. We here review evidence supporting the hypothesis that macrophages play a role in the production and secretion of extracellular ferritin, as well as evidence supporting a novel function as a signalling molecule and immune regulator. In particular, H-ferritin, which inhibits the proliferation of lymphoid and myeloid cells, may be regarded as a negative regulator of human and murine hematopoiesis. The idea that it also acts as a signalling protein has been supported by the cloning and characterisation of the specific H-ferritin receptor TIM-2, a member of the TIM gene family. A number of studies of the mouse TIM gene family indicate that this protein plays an important role in immune-mediated diseases. This last finding, together with the fact that ferritin acts as an immuno-suppressor, has allowed us to formulate hypotheses regarding the possible role of alterations of H-ferritin/TIM-2 binding/signalling in the pathogenesis of autoimmune diseases.",
keywords = "Autoimmune diseases, Ferritin, TIM gene family",
author = "Stefania Recalcati and Pietro Invernizzi and Paolo Arosio and Gaetano Cairo",
year = "2008",
month = "2",
doi = "10.1016/j.jaut.2007.11.003",
language = "English (US)",
volume = "30",
pages = "84--89",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Academic Press Inc.",
number = "1-2",

}

TY - JOUR

T1 - New functions for an iron storage protein

T2 - The role of ferritin in immunity and autoimmunity

AU - Recalcati, Stefania

AU - Invernizzi, Pietro

AU - Arosio, Paolo

AU - Cairo, Gaetano

PY - 2008/2

Y1 - 2008/2

N2 - Ferritin is a ubiquitous and specialised protein involved in the intracellular storage of iron; it is also present in serum and other biological fluids, although its secretion processes are still unclear. We here review evidence supporting the hypothesis that macrophages play a role in the production and secretion of extracellular ferritin, as well as evidence supporting a novel function as a signalling molecule and immune regulator. In particular, H-ferritin, which inhibits the proliferation of lymphoid and myeloid cells, may be regarded as a negative regulator of human and murine hematopoiesis. The idea that it also acts as a signalling protein has been supported by the cloning and characterisation of the specific H-ferritin receptor TIM-2, a member of the TIM gene family. A number of studies of the mouse TIM gene family indicate that this protein plays an important role in immune-mediated diseases. This last finding, together with the fact that ferritin acts as an immuno-suppressor, has allowed us to formulate hypotheses regarding the possible role of alterations of H-ferritin/TIM-2 binding/signalling in the pathogenesis of autoimmune diseases.

AB - Ferritin is a ubiquitous and specialised protein involved in the intracellular storage of iron; it is also present in serum and other biological fluids, although its secretion processes are still unclear. We here review evidence supporting the hypothesis that macrophages play a role in the production and secretion of extracellular ferritin, as well as evidence supporting a novel function as a signalling molecule and immune regulator. In particular, H-ferritin, which inhibits the proliferation of lymphoid and myeloid cells, may be regarded as a negative regulator of human and murine hematopoiesis. The idea that it also acts as a signalling protein has been supported by the cloning and characterisation of the specific H-ferritin receptor TIM-2, a member of the TIM gene family. A number of studies of the mouse TIM gene family indicate that this protein plays an important role in immune-mediated diseases. This last finding, together with the fact that ferritin acts as an immuno-suppressor, has allowed us to formulate hypotheses regarding the possible role of alterations of H-ferritin/TIM-2 binding/signalling in the pathogenesis of autoimmune diseases.

KW - Autoimmune diseases

KW - Ferritin

KW - TIM gene family

UR - http://www.scopus.com/inward/record.url?scp=38049054790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049054790&partnerID=8YFLogxK

U2 - 10.1016/j.jaut.2007.11.003

DO - 10.1016/j.jaut.2007.11.003

M3 - Article

C2 - 18191543

AN - SCOPUS:38049054790

VL - 30

SP - 84

EP - 89

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

IS - 1-2

ER -