Abstract
New discoveries in the retina have provided a unique view of how dopamine (DA) operates as a neurotransmitter. In certain fish retinae, DA, acting through D-1 receptors linked to adenylate cyclase, serves to uncouple electrical synapses between horizontal cells. In other fish species, DA induces the physical retraction of cones and the elongation of rods by an action on D-2 receptors localized to the photoreceptor membrane. These novel actions of DA provide important clues for investigating the physiological role of DA elsewhere in the nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 200-205 |
| Number of pages | 6 |
| Journal | Trends in Neurosciences |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
New directions in neurotransmitter action : dopamine provides some important clues. / Rogawski, Michael A.
In: Trends in Neurosciences, Vol. 10, No. 5, 1987, p. 200-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New directions in neurotransmitter action
T2 - dopamine provides some important clues
AU - Rogawski, Michael A
PY - 1987
Y1 - 1987
N2 - New discoveries in the retina have provided a unique view of how dopamine (DA) operates as a neurotransmitter. In certain fish retinae, DA, acting through D-1 receptors linked to adenylate cyclase, serves to uncouple electrical synapses between horizontal cells. In other fish species, DA induces the physical retraction of cones and the elongation of rods by an action on D-2 receptors localized to the photoreceptor membrane. These novel actions of DA provide important clues for investigating the physiological role of DA elsewhere in the nervous system.
AB - New discoveries in the retina have provided a unique view of how dopamine (DA) operates as a neurotransmitter. In certain fish retinae, DA, acting through D-1 receptors linked to adenylate cyclase, serves to uncouple electrical synapses between horizontal cells. In other fish species, DA induces the physical retraction of cones and the elongation of rods by an action on D-2 receptors localized to the photoreceptor membrane. These novel actions of DA provide important clues for investigating the physiological role of DA elsewhere in the nervous system.
UR - http://www.scopus.com/inward/record.url?scp=0023090781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023090781&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(87)90151-2
DO - 10.1016/0166-2236(87)90151-2
M3 - Article
AN - SCOPUS:0023090781
VL - 10
SP - 200
EP - 205
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 5
ER -