New directions for studying cognitive decline in old monkeys

Peter R. Rapp, Mary T. Kansky, Jeffrey A Roberts, Howard Eichenbaum

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A cognitive neuroscience perspective provides a valuable framework for organizing data on the behavioral consequences of aging in nonhuman primates. Growing evidence suggests that working memory processes known to depend on the functional integrity of the prefrontal cortex are particularly susceptible to aging in the monkey. By comparison, the status of memory supported by the hippocampus and related medial temporal lobe structures appears more variable across aged individuals. Combined with recent conceptual advances in the broader field of learning and memory research, these findings provide a solid foundation for developing new strategies to establish a complete neuropsychological account of cognitive aging in the monkey.

Original languageEnglish (US)
Pages (from-to)369-377
Number of pages9
JournalSeminars in Neuroscience
Volume6
Issue number6
DOIs
StatePublished - Dec 1994

Keywords

  • aging/learning/memory/monkey/neuropsychology

ASJC Scopus subject areas

  • Neuroscience(all)

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