New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation

Tolulope A. Aweda, Vahid Eskandari, David L. Kukis, David L. Boucher, Bernadette V. Marquez, Heather E. Beck, Gregory Mitchell, Simon R Cherry, Claude F. Meares

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We describe the synthesis and development of new reactive DOTA-metal complexes for covalently targeting engineered receptors in vivo, which have superior tumor uptake and clearance properties for biomedical applications. These probes are found to clear efficiently through the kidneys and minimally through other routes, but bind persistently in the tumor target. We also explore the new technique of Cerenkov luminescence imaging to optically monitor radiolabeled probe distribution and kinetics in vivo. Cerenkov luminescence imaging uniquely enables sensitive noninvasive in vivo imaging of a β - emitter such as 90Y with an optical imager.

Original languageEnglish (US)
Pages (from-to)1479-1483
Number of pages5
JournalBioconjugate Chemistry
Volume22
Issue number8
DOIs
StatePublished - Aug 17 2011

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Organic Chemistry
  • Pharmaceutical Science
  • Biomedical Engineering
  • Pharmacology

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