New biomaterials, stem cells and morphogens for tissue engineering

Research output: Contribution to journalArticlepeer-review


Tissue engineering is the science of design and manufacture of new tissues for the functional restoration of failed organs and replacement of lost parts due to diseases, trauma and tumors. The three key ingredients for tissue engineering are morphogenetic signals, responding stem cells and the extracellular matrix scaffolding. The extracellular matrix in skeletal structures is mainly collagenous in nature and in mineralized tissue it consists of hydroxyapatite a bioceramic. The demineralized extracellular matrix of bone has the potential to induce new bone formation. This is a prototype paradigm to demonstrate the proof of principle that a matrix divested of living cells has the property of inducing new bone. Recent progress in new biomaterials, stem cells and morphogenetic signals has set the stage for systematic advances in tissue engineering.

Original languageEnglish (US)
Pages (from-to)459-462
Number of pages4
JournalKey Engineering Materials
StatePublished - 2001

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites


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