New aspects of some endemic mycoses

R. Poncio Mendes, R. Negroni, A. Bonifaz, Demosthenes Pappagianis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The treatment of mycetomas varies according to their etiological agents and the clinical state of the patient. For the treatment of eumycetomas, the azole derivatives are the drugs of choice, with itraconazole rendering better results than ketoconazole and presenting better tolerance. Actinomycetomas are treated according to different therapeutic schemes: dapsone plus sulfamethoxazol-trimethoprim (SMT), and streptomycin or amikacin or amoxicillin plus clavulanic acid. The first therapeutic scheme is very useful in the treatment of Nocardia mycetoma, while the association of amikacin plus SMT is the best treatment for those cases produced by Actinomadura madurae. Ciprofloxacin is a very useful drug for the treatment of actinomycotic mycetomas with bone lesions. Although there are several criteria for evaluating clinical outcome there is no accepted criterion of cure. During the 1990s, there was a remarkable increase in the incidence of coccidioidomycosis in California, USA. An almost ten-fold increase in the number of cases was registered during 1992 and 1993 over the usual incidence. A gradual reduction in coccidioidomycosis cases was observed in the late 1990s. This particular coccidioidomycosis outbreak took place in areas of low endemicity, as well as in those of usual high endemicity. Among the factors believed to have influenced this phenomenon were a drought followed by abundant winter/spring rainfall, increased immigration of susceptible individuals, increase in excavation/construction work and a better diagnosis of the infection, particularly in the last part of the decade. The majority of patients presented the usual clinical manifestations of symptomatic primary infection but an unusual number of cases with acute respiratory failure were observed.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalMedical Mycology
Volume38
Issue numberSUPPL. 1
StatePublished - 2000

Fingerprint

coccidioidomycosis
Mycoses
mycoses
Mycetoma
amikacin
sulfamethoxazole
trimethoprim
Actinomadura madurae
Coccidioidomycosis
indigenous species
dapsone
Nocardia
clavulanic acid
incidence
azoles
ketoconazole
therapeutics
itraconazole
amoxicillin
etiological agents

Keywords

  • Coccidioidomycosis
  • Epidemiology
  • Mycetoma
  • Treatment

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

Cite this

Poncio Mendes, R., Negroni, R., Bonifaz, A., & Pappagianis, D. (2000). New aspects of some endemic mycoses. Medical Mycology, 38(SUPPL. 1), 237-241.

New aspects of some endemic mycoses. / Poncio Mendes, R.; Negroni, R.; Bonifaz, A.; Pappagianis, Demosthenes.

In: Medical Mycology, Vol. 38, No. SUPPL. 1, 2000, p. 237-241.

Research output: Contribution to journalArticle

Poncio Mendes, R, Negroni, R, Bonifaz, A & Pappagianis, D 2000, 'New aspects of some endemic mycoses', Medical Mycology, vol. 38, no. SUPPL. 1, pp. 237-241.
Poncio Mendes R, Negroni R, Bonifaz A, Pappagianis D. New aspects of some endemic mycoses. Medical Mycology. 2000;38(SUPPL. 1):237-241.
Poncio Mendes, R. ; Negroni, R. ; Bonifaz, A. ; Pappagianis, Demosthenes. / New aspects of some endemic mycoses. In: Medical Mycology. 2000 ; Vol. 38, No. SUPPL. 1. pp. 237-241.
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