New approaches to disease mapping in admixed populations

Michael F Seldin, Bogdan Pasaniuc, Alkes L. Price

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Admixed populations such as African Americans and Hispanic Americans are often medically underserved and bear a disproportionately high burden of disease. Owing to the diversity of their genomes, these populations have both advantages and disadvantages for genetic studies of complex phenotypes. Advances in statistical methodologies that can infer genetic contributions from ancestral populations may yield new insights into the aetiology of disease and may contribute to the applicability of genomic medicine to these admixed population groups.

Original languageEnglish (US)
Pages (from-to)523-528
Number of pages6
JournalNature Reviews Genetics
Volume12
Issue number8
DOIs
StatePublished - Aug 2011

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Population
Population Groups
Hispanic Americans
African Americans
Medicine
Genome
Phenotype

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

New approaches to disease mapping in admixed populations. / Seldin, Michael F; Pasaniuc, Bogdan; Price, Alkes L.

In: Nature Reviews Genetics, Vol. 12, No. 8, 08.2011, p. 523-528.

Research output: Contribution to journalArticle

Seldin, Michael F ; Pasaniuc, Bogdan ; Price, Alkes L. / New approaches to disease mapping in admixed populations. In: Nature Reviews Genetics. 2011 ; Vol. 12, No. 8. pp. 523-528.
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