New approaches in the pharmacotherapy of posttraumatic stress disorder

J. M. Silver, D. P. Sandberg, Robert E Hales

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Posttraumatic stress disorder (PTSD) may develop after exposure to severe stress, such as combat, accidents, assaults, and natural disasters. Pharmacotherapy can be a useful adjunct in the comprehensive treatment of these patients. The presence of comorbid conditions, including depression, panic disorder, substance abuse, and traumatic brain injury, should be carefully evaluated. Symptoms of PTSD that are associated with central nervous system hyperarousal or reexperiencing of the traumatic event appear to be the most responsive to pharmacotherapy. Social withdrawal and dulled responsiveness have not been shown to be alleviated through standard pharmacologic interventions. A therapeutic strategy is proposed that is based on the patient's symptoms and initial response to medication.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalJournal of Clinical Psychiatry
Issue number10 SUPPL.
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology


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