New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes

Iman Saramipoor Behbahan, YuYou Duan, Alexander Lam, Shiva Khoobyari, Xiaocui Ma, Tijess P. Ahuja, Mark A Zern

Research output: Contribution to journalArticle

61 Scopus citations


Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells, possessing the ability to produce functional hepatocytes for clinical applications and drug development, may provide the answer to this problem. New discoveries in the mechanisms of liver development and the emergence of induced pluripotent stem cells in 2006 have provided novel insights into hepatocyte differentiation and the use of stem cells for therapeutic applications. This review is aimed towards providing scientists and physicians with the latest advancements in this rapidly progressing field.

Original languageEnglish (US)
Pages (from-to)748-759
Number of pages12
JournalStem Cell Reviews and Reports
Issue number3
StatePublished - Sep 2011



  • Hepatocyte
  • Hepatocyte differentiation
  • Hepatocyte transplantation
  • Human embryonic stem cells
  • Induced pluripotent stem cells

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology

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