New approach to understanding Starling's law at the microstructural level

Xiaping Hu, Fitzroy Curry, Sheldon Weinbaum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A new theory is presented to describe the detailed structure of the osmotic gradients and the flow across the endothelial surface glycocalyx, the inter-endothelial cleft, and the exit region downstream of the cleft exit. The nonlinear coupling of the local fluid flow to the local plasma protein concentration is examined. The primary gradient in osmotic force is felt across the surface layer of matrix. The model shows that there is an unrecognized large asymmetry in the fluid flow pattern on each side of the junction strand and the water enters the cleft nearly uniformly along its length despite the widely separated discrete breaks in the junction strand.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
EditorsW.S. Chang, A. Gopinath, S.S. Sadhal, E.H. Trinh, C.J. Kim, al et al
Place of PublicationFairfield, NJ, United States
PublisherASME
Pages73
Number of pages1
Volume36
Publication statusPublished - 1997
Externally publishedYes
EventProceedings of the 1997 ASME International Mechanical Engineering Congress and Exposition - Dallas, TX, USA
Duration: Nov 16 1997Nov 21 1997

Other

OtherProceedings of the 1997 ASME International Mechanical Engineering Congress and Exposition
CityDallas, TX, USA
Period11/16/9711/21/97

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hu, X., Curry, F., & Weinbaum, S. (1997). New approach to understanding Starling's law at the microstructural level. In W. S. Chang, A. Gopinath, S. S. Sadhal, E. H. Trinh, C. J. Kim, & A. et al (Eds.), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 36, pp. 73). Fairfield, NJ, United States: ASME.