New approach to understanding Starling's law at the microstructural level

Xiaping Hu; Fitzroy Curry; Sheldon Weinbaum

New approach to understanding Starling's law at the microstructural level

Xiaping Hu, Fitzroy Curry, Sheldon Weinbaum

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A new theory is presented to describe the detailed structure of the osmotic gradients and the flow across the endothelial surface glycocalyx, the inter-endothelial cleft, and the exit region downstream of the cleft exit. The nonlinear coupling of the local fluid flow to the local plasma protein concentration is examined. The primary gradient in osmotic force is felt across the surface layer of matrix. The model shows that there is an unrecognized large asymmetry in the fluid flow pattern on each side of the junction strand and the water enters the cleft nearly uniformly along its length despite the widely separated discrete breaks in the junction strand.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Editors	W.S. Chang, A. Gopinath, S.S. Sadhal, E.H. Trinh, C.J. Kim, al et al
Place of Publication	Fairfield, NJ, United States
Publisher	ASME
Pages	73
Number of pages	1
Volume	36
State	Published - 1997
Externally published	Yes
Event	Proceedings of the 1997 ASME International Mechanical Engineering Congress and Exposition - Dallas, TX, USA Duration: Nov 16 1997 → Nov 21 1997

Other

Other	Proceedings of the 1997 ASME International Mechanical Engineering Congress and Exposition
City	Dallas, TX, USA
Period	11/16/97 → 11/21/97

ASJC Scopus subject areas

Engineering(all)

Cite this

New approach to understanding Starling's law at the microstructural level. / Hu, Xiaping; Curry, Fitzroy; Weinbaum, Sheldon.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. ed. / W.S. Chang; A. Gopinath; S.S. Sadhal; E.H. Trinh; C.J. Kim; al et al. Vol. 36 Fairfield, NJ, United States : ASME, 1997. p. 73.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hu, X, Curry, F & Weinbaum, S 1997, New approach to understanding Starling's law at the microstructural level. in WS Chang, A Gopinath, SS Sadhal, EH Trinh, CJ Kim & A et al (eds), American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 36, ASME, Fairfield, NJ, United States, pp. 73, Proceedings of the 1997 ASME International Mechanical Engineering Congress and Exposition, Dallas, TX, USA, 11/16/97.

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AB - A new theory is presented to describe the detailed structure of the osmotic gradients and the flow across the endothelial surface glycocalyx, the inter-endothelial cleft, and the exit region downstream of the cleft exit. The nonlinear coupling of the local fluid flow to the local plasma protein concentration is examined. The primary gradient in osmotic force is felt across the surface layer of matrix. The model shows that there is an unrecognized large asymmetry in the fluid flow pattern on each side of the junction strand and the water enters the cleft nearly uniformly along its length despite the widely separated discrete breaks in the junction strand.

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New approach to understanding Starling's law at the microstructural level

Abstract

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ASJC Scopus subject areas

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