Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar typhimurium colitis

Alanna M. Spees, Dawn D. Kingsbury, Tamding Wangdi, Mariana N. Xavier, Renee M Tsolis, Andreas J Baumler

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Gamma interferon (IFN-γ) is an important driver of intestinal inflammation during colitis caused by Salmonella enterica serovar Typhimurium. Here we used the mouse colitis model to investigate the cellular sources of IFN-γ in the cecal mucosa during the acute phase of an S. Typhimurium infection. While IFN-γ staining was detected in T cells, NK cells, and inflammatory monocytes at 2 days after infection, the majority of IFN-γ-positive cells in the cecal mucosa were neutrophils. Furthermore, neutrophil depletion blunted mucosal Ifng expression and reduced the severity of intestinal lesions during S. Typhimurium infection. We conclude that neutrophils are a prominent cellular source of IFN-γ during the innate phase of S. Typhimurium-induced colitis.

Original languageEnglish (US)
Pages (from-to)1692-1697
Number of pages6
JournalInfection and Immunity
Volume82
Issue number4
DOIs
StatePublished - 2014

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ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Parasitology
  • Infectious Diseases

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