Neutrophil influx during non-typhoidal salmonellosis: Who is in the driver's seat?

Çagla Tükel, Manuela Raffatellu, Daniela Chessa, R. Paul Wilson, Mustafa Akçelik, Andreas J Baumler

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A massive neutrophil influx in the intestine is the histopathological hallmark of Salmonella enterica serovar Typhimurium-induced enterocolitis in humans. Two major hypotheses on the mechanism leading to neutrophil infiltration in the intestinal mucosa have emerged. One hypothesis suggests that S. enterica serovar Typhimurium takes an active role in triggering this host response by injecting proteins, termed effectors, into the host cell cytosol which induce a proinflammatory gene expression profile in the intestinal epithelium. The second hypothesis suggests a more passive role for the pathogen by proposing that bacterial invasion stimulates the innate pathways of inflammation because the pathogen-associated molecular patterns of S. enterica serovar Typhimurium are recognized by pathogen recognition receptors on cells in the lamina propria. A review of the current literature reveals that, while pathogen recognition receptors are clearly involved in eliciting neutrophil influx during S. enterica serovar Typhimurium infection, a direct contribution of effectors in triggering proinflammatory host cell responses cannot currently be ruled out.

Original languageEnglish (US)
Pages (from-to)320-329
Number of pages10
JournalFEMS Immunology and Medical Microbiology
Volume46
Issue number3
DOIs
StatePublished - Apr 2006

Fingerprint

Salmonella enterica
Salmonella Infections
Neutrophils
Intestinal Mucosa
Enterocolitis
Neutrophil Infiltration
Transcriptome
Cytosol
Intestines
Mucous Membrane
Inflammation
Serogroup
Infection
Proteins

Keywords

  • Enterocolitis
  • Inflammation
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

Cite this

Neutrophil influx during non-typhoidal salmonellosis : Who is in the driver's seat? / Tükel, Çagla; Raffatellu, Manuela; Chessa, Daniela; Wilson, R. Paul; Akçelik, Mustafa; Baumler, Andreas J.

In: FEMS Immunology and Medical Microbiology, Vol. 46, No. 3, 04.2006, p. 320-329.

Research output: Contribution to journalArticle

Tükel, Çagla ; Raffatellu, Manuela ; Chessa, Daniela ; Wilson, R. Paul ; Akçelik, Mustafa ; Baumler, Andreas J. / Neutrophil influx during non-typhoidal salmonellosis : Who is in the driver's seat?. In: FEMS Immunology and Medical Microbiology. 2006 ; Vol. 46, No. 3. pp. 320-329.
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