Neutron reflectivity study of lipid membranes assembled on ordered nanocomposite and nanoporous silica thin films

Dhaval A. Doshi, Andrew M. Dattelbaum, Erik B. Watkins, C. Jeffrey Brinker, Basil I. Swanson, Andrew P. Shreve, Atul N. Parikh, Jaroslaw Majewski

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Single bilayer membranes of l-palmitoyl-2-oleoyl-sn-glycero-3- phosphocholine (POPC) were formed on ordered nanocomposite and nanoporous silica thin films by fusion of small unilamellar vesicles. The structure of these membranes was investigated using neutron reflectivity. The underlying thin films were formed by evaporation induced self-assembly to obtain periodic arrangements of silica and surfactant molecules in the nanocomposite thin films, followed by photocalcination to oxidatively remove the organics and render the films nanoporous. We show that this platform affords homogeneous and continuous bilayer membranes that have promising applications as model membranes and sensors.

Original languageEnglish (US)
Pages (from-to)2865-2870
Number of pages6
JournalLangmuir
Volume21
Issue number7
DOIs
StatePublished - Mar 29 2005

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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