Neutralization epitope in the envelope glycoprotein of simian retrovirus-1 (SRV-1) and identification of the virus receptor.

Jose V Torres, L. L. Werner, A. Malley, E. Benjamin

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We previously demonstrated that the area encompassing residues 147-162 of the envelope protein of simian retrovirus serotype-1 (SRV-1) is the target for rhesus anti-SRV-1 neutralizing antibodies. A peptide representing amino acids 142-167 of envelope protein (gp70) is capable of inducing virus-neutralizing antibodies in mice. The virus receptor was immunoprecipitated from Raji cells using gp70 as the ligand. Antibodies to peptide 142-167 inhibit the immunoprecipitation, indicating that the receptor recognizes residues 142-167 of the viral envelope protein.

Original languageEnglish (US)
Pages (from-to)218-221
Number of pages4
JournalJournal of Medical Primatology
Volume20
Issue number4
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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