Neurotropin improves the thymic microenvironment and nephritis in (NXB x NZW)F1 mice

Y. Takeoka, M. Naiki, R. L. Boyd, H. Yago, S. Suehiro, M. Eric Gershwin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Neurotropin, which is a unique non-protein extract isolated from the inflamed dermis of rabbits inoculated with vaccinia virus, has been demonstrated to have beneficial effects in immune-suppressed or autoimmune animals. To further understand the mechanism of action of Neurotropin, we examined its effects on the thymic microenvironment renal pathology and levels of anti-DNA antibodies in (NZB x NZW)F1 mice, one of the principal murine lupus models. We have previously reported that (NZB x NZW)F1 mice or other murine lupus models have distinctive abnormalities in their thymic microenvironment. in this study we have taken advantage of a well-characterized panel of monoclonal antibodies that recognize cortical, medullary, and non-epithelial elements within the thymic architecture. Neurotropin significantly improved several thymic cortical and medullary abnormalities including irregular shape, diffused networks and/or reduced staining in 6-month-old (NZB x NZW)F1 mice by treatment with 40 Neurotropin unit/kg body weight by daily i.p. injection for 14 days with data similar to age-matched BALB/c mice. Neurotropin also improved the abnormalities of extracellular matrix which expressed abnormal shapes and was increased markedly in the thymus of 6-month-old (NZB x NZW)F1 mice. The architecture of the extracellular matrix in Neurotropin-treated (NZB x NZW)F1 mice expressed a similar shape as age-matched control BALB/c mice. Moreover Neurotropin significantly reduced proteinuria in (NZB x NZW)F1 mice compared to proteinuria in saline-treated (NZB x NZW)F1 mice which showed high levels. The results suggest that Neurotropin has beneficial effects on architectural abnormalities of thymus and nephritic syndromes, and may be important in the treatment of human patients with systemic lupus erythematosus (SLE).

Original languageEnglish (US)
Pages (from-to)45-54
Number of pages10
JournalInternational Journal of Immunotherapy
Volume13
Issue number1-2
StatePublished - 1997

Fingerprint

Nephritis
Proteinuria
Thymus Gland
Extracellular Matrix
Kidney
neurotropin
Vaccinia virus
Antinuclear Antibodies
Dermis
Systemic Lupus Erythematosus
Monoclonal Antibodies
Body Weight
Pathology
Staining and Labeling
Rabbits
Injections
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Neurotropin improves the thymic microenvironment and nephritis in (NXB x NZW)F1 mice. / Takeoka, Y.; Naiki, M.; Boyd, R. L.; Yago, H.; Suehiro, S.; Gershwin, M. Eric.

In: International Journal of Immunotherapy, Vol. 13, No. 1-2, 1997, p. 45-54.

Research output: Contribution to journalArticle

Takeoka, Y, Naiki, M, Boyd, RL, Yago, H, Suehiro, S & Gershwin, ME 1997, 'Neurotropin improves the thymic microenvironment and nephritis in (NXB x NZW)F1 mice', International Journal of Immunotherapy, vol. 13, no. 1-2, pp. 45-54.
Takeoka, Y. ; Naiki, M. ; Boyd, R. L. ; Yago, H. ; Suehiro, S. ; Gershwin, M. Eric. / Neurotropin improves the thymic microenvironment and nephritis in (NXB x NZW)F1 mice. In: International Journal of Immunotherapy. 1997 ; Vol. 13, No. 1-2. pp. 45-54.
@article{b0cdf8bfd4594a558212af568d796a0d,
title = "Neurotropin improves the thymic microenvironment and nephritis in (NXB x NZW)F1 mice",
abstract = "Neurotropin, which is a unique non-protein extract isolated from the inflamed dermis of rabbits inoculated with vaccinia virus, has been demonstrated to have beneficial effects in immune-suppressed or autoimmune animals. To further understand the mechanism of action of Neurotropin, we examined its effects on the thymic microenvironment renal pathology and levels of anti-DNA antibodies in (NZB x NZW)F1 mice, one of the principal murine lupus models. We have previously reported that (NZB x NZW)F1 mice or other murine lupus models have distinctive abnormalities in their thymic microenvironment. in this study we have taken advantage of a well-characterized panel of monoclonal antibodies that recognize cortical, medullary, and non-epithelial elements within the thymic architecture. Neurotropin significantly improved several thymic cortical and medullary abnormalities including irregular shape, diffused networks and/or reduced staining in 6-month-old (NZB x NZW)F1 mice by treatment with 40 Neurotropin unit/kg body weight by daily i.p. injection for 14 days with data similar to age-matched BALB/c mice. Neurotropin also improved the abnormalities of extracellular matrix which expressed abnormal shapes and was increased markedly in the thymus of 6-month-old (NZB x NZW)F1 mice. The architecture of the extracellular matrix in Neurotropin-treated (NZB x NZW)F1 mice expressed a similar shape as age-matched control BALB/c mice. Moreover Neurotropin significantly reduced proteinuria in (NZB x NZW)F1 mice compared to proteinuria in saline-treated (NZB x NZW)F1 mice which showed high levels. The results suggest that Neurotropin has beneficial effects on architectural abnormalities of thymus and nephritic syndromes, and may be important in the treatment of human patients with systemic lupus erythematosus (SLE).",
author = "Y. Takeoka and M. Naiki and Boyd, {R. L.} and H. Yago and S. Suehiro and Gershwin, {M. Eric}",
year = "1997",
language = "English (US)",
volume = "13",
pages = "45--54",
journal = "International Journal of Immunotherapy",
issn = "0255-9625",
publisher = "Bioscience Ediprint Inc.",
number = "1-2",

}

TY - JOUR

T1 - Neurotropin improves the thymic microenvironment and nephritis in (NXB x NZW)F1 mice

AU - Takeoka, Y.

AU - Naiki, M.

AU - Boyd, R. L.

AU - Yago, H.

AU - Suehiro, S.

AU - Gershwin, M. Eric

PY - 1997

Y1 - 1997

N2 - Neurotropin, which is a unique non-protein extract isolated from the inflamed dermis of rabbits inoculated with vaccinia virus, has been demonstrated to have beneficial effects in immune-suppressed or autoimmune animals. To further understand the mechanism of action of Neurotropin, we examined its effects on the thymic microenvironment renal pathology and levels of anti-DNA antibodies in (NZB x NZW)F1 mice, one of the principal murine lupus models. We have previously reported that (NZB x NZW)F1 mice or other murine lupus models have distinctive abnormalities in their thymic microenvironment. in this study we have taken advantage of a well-characterized panel of monoclonal antibodies that recognize cortical, medullary, and non-epithelial elements within the thymic architecture. Neurotropin significantly improved several thymic cortical and medullary abnormalities including irregular shape, diffused networks and/or reduced staining in 6-month-old (NZB x NZW)F1 mice by treatment with 40 Neurotropin unit/kg body weight by daily i.p. injection for 14 days with data similar to age-matched BALB/c mice. Neurotropin also improved the abnormalities of extracellular matrix which expressed abnormal shapes and was increased markedly in the thymus of 6-month-old (NZB x NZW)F1 mice. The architecture of the extracellular matrix in Neurotropin-treated (NZB x NZW)F1 mice expressed a similar shape as age-matched control BALB/c mice. Moreover Neurotropin significantly reduced proteinuria in (NZB x NZW)F1 mice compared to proteinuria in saline-treated (NZB x NZW)F1 mice which showed high levels. The results suggest that Neurotropin has beneficial effects on architectural abnormalities of thymus and nephritic syndromes, and may be important in the treatment of human patients with systemic lupus erythematosus (SLE).

AB - Neurotropin, which is a unique non-protein extract isolated from the inflamed dermis of rabbits inoculated with vaccinia virus, has been demonstrated to have beneficial effects in immune-suppressed or autoimmune animals. To further understand the mechanism of action of Neurotropin, we examined its effects on the thymic microenvironment renal pathology and levels of anti-DNA antibodies in (NZB x NZW)F1 mice, one of the principal murine lupus models. We have previously reported that (NZB x NZW)F1 mice or other murine lupus models have distinctive abnormalities in their thymic microenvironment. in this study we have taken advantage of a well-characterized panel of monoclonal antibodies that recognize cortical, medullary, and non-epithelial elements within the thymic architecture. Neurotropin significantly improved several thymic cortical and medullary abnormalities including irregular shape, diffused networks and/or reduced staining in 6-month-old (NZB x NZW)F1 mice by treatment with 40 Neurotropin unit/kg body weight by daily i.p. injection for 14 days with data similar to age-matched BALB/c mice. Neurotropin also improved the abnormalities of extracellular matrix which expressed abnormal shapes and was increased markedly in the thymus of 6-month-old (NZB x NZW)F1 mice. The architecture of the extracellular matrix in Neurotropin-treated (NZB x NZW)F1 mice expressed a similar shape as age-matched control BALB/c mice. Moreover Neurotropin significantly reduced proteinuria in (NZB x NZW)F1 mice compared to proteinuria in saline-treated (NZB x NZW)F1 mice which showed high levels. The results suggest that Neurotropin has beneficial effects on architectural abnormalities of thymus and nephritic syndromes, and may be important in the treatment of human patients with systemic lupus erythematosus (SLE).

UR - http://www.scopus.com/inward/record.url?scp=0031396407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031396407&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031396407

VL - 13

SP - 45

EP - 54

JO - International Journal of Immunotherapy

JF - International Journal of Immunotherapy

SN - 0255-9625

IS - 1-2

ER -