Encefalitis asociada a astrovirus bovino neurotrópico, ¿una enfermedad subdiagnosticada en Sudamérica?

Translated title of the contribution: Neurotropic bovine astrovirus-associated encephalitis: An underdiagnosed disease in South America?

Benjamín Doncel Díaz, Matías Castells, Leticia Maya, Martín Fraga, Francisco A. Uzal, Rodney Colina, Federico Giannitti

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a case of neurotropic bovine astrovirus-associated encephalitis in a Jersey dairy cow from the department of San José, Uruguay. This represents the second case of this condition reported in the Southern Hemisphere. The cow was the only one affected in a herd of 70 cows, showing neurological signs with a 2-day clinical course, before dying spontaneously. Histopathological examination revealed lymphocytic, histiocytic, and plasmacytic meningoencephalitis with neuronal necrosis, without detectable inclusion bodies. Other infectious agents, including Rabies virus (Lyssavirus), Bovine alphaherpesvirus-1 and Bovine alphaherpesvirus-5 (Varicellovirus), Bovine viral diarrhea virus (Pestivirus), West Nile virus (Flavivirus), Listeria monocytogenes, Histophilus somni and other bacteria, were not detected in the brain. We propose that given the recent discovery of neurotropic astroviruses in various mammalian species, including humans, cases of astrovirus encephalitis may have gone undetected in South America. We briefly discuss the differential pathologic diagnosis of infectious bovine encephalitis.

Translated title of the contributionNeurotropic bovine astrovirus-associated encephalitis: An underdiagnosed disease in South America?
Original languageSpanish
JournalRevista Argentina de Microbiologia
DOIs
StateAccepted/In press - 2021

Keywords

  • Bovine astrovirus
  • Dairy cows
  • Neurological disease
  • Uruguay

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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