Abstract
Neurotrophins have been proposed to mediate several forms of activity- dependent competition in the central nervous system. A key element of such hypotheses is that neurotrophins act preferentially on active neurons; however, little direct evidence supports this postulate. We therefore examined, in ferret cortical brain slices, the interactions between activity and neurotrophins in regulating dendritic growth of layer 4 pyramidal neurons. Inhibition of spontaneous electrical activity, synaptic transmission, or L-type calcium channels each prevented the otherwise dramatic increase in dendritic arborizations elicited by brain-derived neurotrophic factor. In developing cortex, this requirement for conjoint neurotrophin signaling and activity provides a mechanism for selectively enhancing the growth and connectivity of active neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1057-1064 |
| Number of pages | 8 |
| Journal | Neuron |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Neurotrophin regulation of cortical dendritic growth requires activity. / Usrey, A Kimberley; Katz, Lawrence C.; Lo, Donald C.
In: Neuron, Vol. 17, No. 6, 12.1996, p. 1057-1064.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurotrophin regulation of cortical dendritic growth requires activity
AU - Usrey, A Kimberley
AU - Katz, Lawrence C.
AU - Lo, Donald C.
PY - 1996/12
Y1 - 1996/12
N2 - Neurotrophins have been proposed to mediate several forms of activity- dependent competition in the central nervous system. A key element of such hypotheses is that neurotrophins act preferentially on active neurons; however, little direct evidence supports this postulate. We therefore examined, in ferret cortical brain slices, the interactions between activity and neurotrophins in regulating dendritic growth of layer 4 pyramidal neurons. Inhibition of spontaneous electrical activity, synaptic transmission, or L-type calcium channels each prevented the otherwise dramatic increase in dendritic arborizations elicited by brain-derived neurotrophic factor. In developing cortex, this requirement for conjoint neurotrophin signaling and activity provides a mechanism for selectively enhancing the growth and connectivity of active neurons.
AB - Neurotrophins have been proposed to mediate several forms of activity- dependent competition in the central nervous system. A key element of such hypotheses is that neurotrophins act preferentially on active neurons; however, little direct evidence supports this postulate. We therefore examined, in ferret cortical brain slices, the interactions between activity and neurotrophins in regulating dendritic growth of layer 4 pyramidal neurons. Inhibition of spontaneous electrical activity, synaptic transmission, or L-type calcium channels each prevented the otherwise dramatic increase in dendritic arborizations elicited by brain-derived neurotrophic factor. In developing cortex, this requirement for conjoint neurotrophin signaling and activity provides a mechanism for selectively enhancing the growth and connectivity of active neurons.
UR - http://www.scopus.com/inward/record.url?scp=0030475493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030475493&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(00)80239-1
DO - 10.1016/S0896-6273(00)80239-1
M3 - Article
C2 - 8982155
AN - SCOPUS:0030475493
VL - 17
SP - 1057
EP - 1064
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 6
ER -