Abstract
We report that stimulation inducing long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF and NT-3 mRNAs in CA1 neurons. No changes in BDNF or NT-3 mRNA levels were seen in the nonstimulated regions of the pyramidal cell layer or the dentate. No change was seen in the levels of NGF mRNA at the time point examined. These results suggest that relatively normal levels of activity may regulate region-specific neurotrophin levels in the hippocampus. Given that known effects of NGF (and presumably of BDNF and NT-3) include elevation of neurotransmitter levels, elevation of sodium channels, and promotion of axonal terminal sprouting, activity-associated changes in neurotrophin levels may play a role in regulating neural connections in the adult as well as the developing nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1081-1088 |
| Number of pages | 8 |
| Journal | Neuron |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neurotrophin expression in rat hippocampal slices : A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. / Patterson, Susan L.; Grover, Larry M.; Schwartzkroin, Philip A; Bothwell, Mark.
In: Neuron, Vol. 9, No. 6, 1992, p. 1081-1088.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurotrophin expression in rat hippocampal slices
T2 - A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
AU - Patterson, Susan L.
AU - Grover, Larry M.
AU - Schwartzkroin, Philip A
AU - Bothwell, Mark
PY - 1992
Y1 - 1992
N2 - We report that stimulation inducing long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF and NT-3 mRNAs in CA1 neurons. No changes in BDNF or NT-3 mRNA levels were seen in the nonstimulated regions of the pyramidal cell layer or the dentate. No change was seen in the levels of NGF mRNA at the time point examined. These results suggest that relatively normal levels of activity may regulate region-specific neurotrophin levels in the hippocampus. Given that known effects of NGF (and presumably of BDNF and NT-3) include elevation of neurotransmitter levels, elevation of sodium channels, and promotion of axonal terminal sprouting, activity-associated changes in neurotrophin levels may play a role in regulating neural connections in the adult as well as the developing nervous system.
AB - We report that stimulation inducing long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF and NT-3 mRNAs in CA1 neurons. No changes in BDNF or NT-3 mRNA levels were seen in the nonstimulated regions of the pyramidal cell layer or the dentate. No change was seen in the levels of NGF mRNA at the time point examined. These results suggest that relatively normal levels of activity may regulate region-specific neurotrophin levels in the hippocampus. Given that known effects of NGF (and presumably of BDNF and NT-3) include elevation of neurotransmitter levels, elevation of sodium channels, and promotion of axonal terminal sprouting, activity-associated changes in neurotrophin levels may play a role in regulating neural connections in the adult as well as the developing nervous system.
UR - http://www.scopus.com/inward/record.url?scp=0027075042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027075042&partnerID=8YFLogxK
U2 - 10.1016/0896-6273(92)90067-N
DO - 10.1016/0896-6273(92)90067-N
M3 - Article
C2 - 1463608
AN - SCOPUS:0027075042
VL - 9
SP - 1081
EP - 1088
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 6
ER -