Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

Susan L. Patterson, Larry M. Grover, Philip A Schwartzkroin, Mark Bothwell

Research output: Contribution to journalArticle

461 Citations (Scopus)

Abstract

We report that stimulation inducing long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF and NT-3 mRNAs in CA1 neurons. No changes in BDNF or NT-3 mRNA levels were seen in the nonstimulated regions of the pyramidal cell layer or the dentate. No change was seen in the levels of NGF mRNA at the time point examined. These results suggest that relatively normal levels of activity may regulate region-specific neurotrophin levels in the hippocampus. Given that known effects of NGF (and presumably of BDNF and NT-3) include elevation of neurotransmitter levels, elevation of sodium channels, and promotion of axonal terminal sprouting, activity-associated changes in neurotrophin levels may play a role in regulating neural connections in the adult as well as the developing nervous system.

Original languageEnglish (US)
Pages (from-to)1081-1088
Number of pages8
JournalNeuron
Volume9
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

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Long-Term Potentiation
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Nerve Growth Factor
Messenger RNA
Hippocampus
Hippocampal CA1 Region
Sodium Channels
Pyramidal Cells
Nervous System
Neurotransmitter Agents
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

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Neurotrophin expression in rat hippocampal slices : A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. / Patterson, Susan L.; Grover, Larry M.; Schwartzkroin, Philip A; Bothwell, Mark.

In: Neuron, Vol. 9, No. 6, 1992, p. 1081-1088.

Research output: Contribution to journalArticle

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