Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity

Bryan Kavanaugh, Jacqueline Beesley, Takayuki Ito, Aki Itoh, Judith Grinspan, David E Pleasure

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA. We now report that: a) oligodendroglial progenitors (OP) and immature oligodendroglia are more vulnerable to AMPA-GluR-mediated excitotoxicity than are mature oligodendroglia; b) TrkC expression falls substantially during differentiation of cultured OP to mature oligodendroglia, whereas TrkA expression increases markedly; and C) neurotrophin-3, and to a lesser extent, nerve growth factor, protect the oligodendroglial lineage against AMPA-GluR-mediated excitotoxicity. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)725-732
Number of pages8
JournalJournal of Neuroscience Research
Volume60
Issue number6
StatePublished - Jun 15 2000
Externally publishedYes

Fingerprint

Neurotrophin 3
AMPA Receptors
Oligodendroglia
Glutamate Receptors
Nerve Growth Factor Receptors
Nerve Growth Factor
Cell Lineage
Necrosis
bucide
propionic acid

Keywords

  • Excitotoxicity
  • Glutamate receptor
  • Nerve growth factor
  • Neurotrophin- 3
  • Oligodendroglia
  • TrkA
  • TrkC

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity. / Kavanaugh, Bryan; Beesley, Jacqueline; Ito, Takayuki; Itoh, Aki; Grinspan, Judith; Pleasure, David E.

In: Journal of Neuroscience Research, Vol. 60, No. 6, 15.06.2000, p. 725-732.

Research output: Contribution to journalArticle

Kavanaugh, Bryan ; Beesley, Jacqueline ; Ito, Takayuki ; Itoh, Aki ; Grinspan, Judith ; Pleasure, David E. / Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity. In: Journal of Neuroscience Research. 2000 ; Vol. 60, No. 6. pp. 725-732.
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