Abstract
Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA. We now report that: a) oligodendroglial progenitors (OP) and immature oligodendroglia are more vulnerable to AMPA-GluR-mediated excitotoxicity than are mature oligodendroglia; b) TrkC expression falls substantially during differentiation of cultured OP to mature oligodendroglia, whereas TrkA expression increases markedly; and C) neurotrophin-3, and to a lesser extent, nerve growth factor, protect the oligodendroglial lineage against AMPA-GluR-mediated excitotoxicity. (C) 2000 Wiley-Liss, Inc.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-732 |
| Number of pages | 8 |
| Journal | Journal of Neuroscience Research |
| Volume | 60 |
| Issue number | 6 |
| State | Published - Jun 15 2000 |
| Externally published | Yes |
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Keywords
- Excitotoxicity
- Glutamate receptor
- Nerve growth factor
- Neurotrophin- 3
- Oligodendroglia
- TrkA
- TrkC
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity. / Kavanaugh, Bryan; Beesley, Jacqueline; Ito, Takayuki; Itoh, Aki; Grinspan, Judith; Pleasure, David E.
In: Journal of Neuroscience Research, Vol. 60, No. 6, 15.06.2000, p. 725-732.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity
AU - Kavanaugh, Bryan
AU - Beesley, Jacqueline
AU - Ito, Takayuki
AU - Itoh, Aki
AU - Grinspan, Judith
AU - Pleasure, David E
PY - 2000/6/15
Y1 - 2000/6/15
N2 - Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA. We now report that: a) oligodendroglial progenitors (OP) and immature oligodendroglia are more vulnerable to AMPA-GluR-mediated excitotoxicity than are mature oligodendroglia; b) TrkC expression falls substantially during differentiation of cultured OP to mature oligodendroglia, whereas TrkA expression increases markedly; and C) neurotrophin-3, and to a lesser extent, nerve growth factor, protect the oligodendroglial lineage against AMPA-GluR-mediated excitotoxicity. (C) 2000 Wiley-Liss, Inc.
AB - Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA. We now report that: a) oligodendroglial progenitors (OP) and immature oligodendroglia are more vulnerable to AMPA-GluR-mediated excitotoxicity than are mature oligodendroglia; b) TrkC expression falls substantially during differentiation of cultured OP to mature oligodendroglia, whereas TrkA expression increases markedly; and C) neurotrophin-3, and to a lesser extent, nerve growth factor, protect the oligodendroglial lineage against AMPA-GluR-mediated excitotoxicity. (C) 2000 Wiley-Liss, Inc.
KW - Excitotoxicity
KW - Glutamate receptor
KW - Nerve growth factor
KW - Neurotrophin- 3
KW - Oligodendroglia
KW - TrkA
KW - TrkC
UR - http://www.scopus.com/inward/record.url?scp=0034660479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034660479&partnerID=8YFLogxK
M3 - Article
C2 - 10861784
AN - SCOPUS:0034660479
VL - 60
SP - 725
EP - 732
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
SN - 0360-4012
IS - 6
ER -