Neurotrophin-3 (NT-3) diminishes susceptibility of the oligodendroglial lineage to AMPA glutamate receptor-mediated excitotoxicity

Bryan Kavanaugh, Jacqueline Beesley, Takayuki Ito, Aki Itoh, Judith Grinspan, David E Pleasure

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA. We now report that: a) oligodendroglial progenitors (OP) and immature oligodendroglia are more vulnerable to AMPA-GluR-mediated excitotoxicity than are mature oligodendroglia; b) TrkC expression falls substantially during differentiation of cultured OP to mature oligodendroglia, whereas TrkA expression increases markedly; and C) neurotrophin-3, and to a lesser extent, nerve growth factor, protect the oligodendroglial lineage against AMPA-GluR-mediated excitotoxicity. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)725-732
Number of pages8
JournalJournal of Neuroscience Research
Volume60
Issue number6
StatePublished - Jun 15 2000
Externally publishedYes

Keywords

  • Excitotoxicity
  • Glutamate receptor
  • Nerve growth factor
  • Neurotrophin- 3
  • Oligodendroglia
  • TrkA
  • TrkC

ASJC Scopus subject areas

  • Neuroscience(all)

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