Abstract
Prior reports demonstrated that cells of the oligodendroglial lineage are susceptible to excitotoxic necrosis mediated by α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid glutamate receptors (AMPA-GluR), and also showed that these cells express the high affinity neurotrophin receptors, TrkC and TrkA. We now report that: a) oligodendroglial progenitors (OP) and immature oligodendroglia are more vulnerable to AMPA-GluR-mediated excitotoxicity than are mature oligodendroglia; b) TrkC expression falls substantially during differentiation of cultured OP to mature oligodendroglia, whereas TrkA expression increases markedly; and C) neurotrophin-3, and to a lesser extent, nerve growth factor, protect the oligodendroglial lineage against AMPA-GluR-mediated excitotoxicity. (C) 2000 Wiley-Liss, Inc.
Original language | English (US) |
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Pages (from-to) | 725-732 |
Number of pages | 8 |
Journal | Journal of Neuroscience Research |
Volume | 60 |
Issue number | 6 |
State | Published - Jun 15 2000 |
Externally published | Yes |
Keywords
- Excitotoxicity
- Glutamate receptor
- Nerve growth factor
- Neurotrophin- 3
- Oligodendroglia
- TrkA
- TrkC
ASJC Scopus subject areas
- Neuroscience(all)