Neurotransmitter-mediated mechanisms of traumatic brain injury: Acetylcholine and excitatory amino acids

R. L. Hayes, L. W. Jenkins, Bruce G Lyeth

Research output: Contribution to journalArticle

255 Citations (Scopus)

Abstract

Research into traumatic brain injury (TBI), focusing on changes in energy metabolism, cerebrovascular dysfunction, and brain parenchymal morphology, has not produced complete descriptions of mechanisms mediating the pathophysiology of TBI. New studies indicate that neurochemical alterations mediate important components of brain physiology associated with TBI, and these alterations may be responsive to pharmacologic therapy. We discuss rodent models of TBI, review current experimental evidence of muscarinic cholinergic and excitatory amino acid (EAA) receptor involvement in its pathophysiology, and address issues relevant to the interpretation of these data.

Original languageEnglish (US)
JournalJournal of Neurotrauma
Volume9
Issue numberSUPPL. 1
StatePublished - 1992
Externally publishedYes

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Excitatory Amino Acids
Acetylcholine
Neurotransmitter Agents
Cholinergic Agents
Glutamate Receptors
Brain
Energy Metabolism
Rodentia
Traumatic Brain Injury
Research
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neurotransmitter-mediated mechanisms of traumatic brain injury : Acetylcholine and excitatory amino acids. / Hayes, R. L.; Jenkins, L. W.; Lyeth, Bruce G.

In: Journal of Neurotrauma, Vol. 9, No. SUPPL. 1, 1992.

Research output: Contribution to journalArticle

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