Neurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and isofenphos to the hen

John D. Henderson, Robert Higgins, Jack C. Dacre, Barry W. Wilson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The neuropathic potential of acute and repeated exposures of the phosphoramidates tabun (GA) and isofenphos (IFP), of diisopropyl fluorophosphate (DFP) and paraoxon (PO) were examined in the hen with treatments for up to 90 days via intramuscular injections of the highest tolerated doses with atropine protection. Plasma acetylcholinesterase (AChE), non-specific butyrylcholinesterase (BChE) and creatine kinase (CK) activities were measured in order to monitor whether the compounds were present at biologically active concentrations. Locomotor behavior was observed and tissues from the peripheral and central nervous systems were examined for signs of organophosphate-induced delayed neuropathy (OPIDN). No behavioral or histological evidence of OPIDN was observed after treatments with GA, IFP, PO, saline or atropine sulfate. DFP-treated birds displayed locomotor and neuropathological signs of OPIDN with a no effect level (NOEL) between 25 and 50 μg/kg.

Original languageEnglish (US)
Pages (from-to)117-129
Number of pages13
JournalToxicology
Volume72
Issue number2
DOIs
StatePublished - Jan 1 1992

Fingerprint

fluorophosphate
Paraoxon
Organophosphates
Atropine
Butyrylcholinesterase
Intramuscular Injections
Peripheral Nervous System
Birds
Neurology
Acetylcholinesterase
Creatine Kinase
Therapeutics
Central Nervous System
Tissue
Plasmas
isofenphos
tabun

Keywords

  • Diisopropyl fluorophosphate
  • Hen
  • Isofenphos
  • Neurotoxicity
  • Organophosphates
  • Paraoxon
  • Tabun

ASJC Scopus subject areas

  • Toxicology

Cite this

Neurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and isofenphos to the hen. / Henderson, John D.; Higgins, Robert; Dacre, Jack C.; Wilson, Barry W.

In: Toxicology, Vol. 72, No. 2, 01.01.1992, p. 117-129.

Research output: Contribution to journalArticle

Henderson, John D. ; Higgins, Robert ; Dacre, Jack C. ; Wilson, Barry W. / Neurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and isofenphos to the hen. In: Toxicology. 1992 ; Vol. 72, No. 2. pp. 117-129.
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