Neurotensin and cholecystokinin microinjected into the ventral tegmental area modulate microdialysate concentrations of dopamine and metabolites in the posterior nucleus accumbens

K. Laitinen, Jacqueline Crawley, I. N. Mefford, Ph De Witte

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Neurotensin and cholecystokinin, neuropeptides which coexist with dopamine in many ventral tegmental neurons, were microinjected into the ventral tegmental area during in vivo microdialysis in the posterior nucleus accumbens. Neurotensin significantly elevated concentrations of dopamine and its metabolites at doses of 10 pmol, 1 nmol, and 10 nmol, while cholecystokinin significantly elevated dopamine metabolite concentrations only at a dose of 10 nmol. These data suggest that neurotensin potently mediates the release of dopamine from the mesolimbic pathway via direct actions on the cell body.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalBrain Research
Volume523
Issue number2
DOIs
StatePublished - Jul 23 1990
Externally publishedYes

Keywords

  • Cholecystokinin
  • Dopamine
  • Mesolimbic
  • Microdialysis
  • Neurotensin
  • Nucleus accumbens
  • Receptor
  • Ventral tegmentum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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