Neuroscience: Synapses form in skeletal muscles lacking neuregulin receptors

P. Escher, E. Lacazette, M. Courtet, A. Blindenbacher, L. Landmann, C. Bezakova, Kevin C K Lloyd, U. Mueller, H. R. Brenner

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

Original languageEnglish (US)
Pages (from-to)1920-1923
Number of pages4
JournalScience
Volume308
Issue number5730
DOIs
StatePublished - Jun 24 2005

ASJC Scopus subject areas

  • General

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    Escher, P., Lacazette, E., Courtet, M., Blindenbacher, A., Landmann, L., Bezakova, C., Lloyd, K. C. K., Mueller, U., & Brenner, H. R. (2005). Neuroscience: Synapses form in skeletal muscles lacking neuregulin receptors. Science, 308(5730), 1920-1923. https://doi.org/10.1126/science.1108258