Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

Vuk Koprivica, Kin Sang Cho, Jong Bae Park, Glenn C Yiu, Jasvinder Atwal, Bryan Gore, Jieun A. Kim, Estelle Lin, Marc Tessier-Lavigne, Dong Feng Chen, Zhigang He

Research output: Contribution to journalArticle

272 Scopus citations

Abstract

Inhibitory molecules associated with myelin and the glial scar limit axon regeneration in the adult central nervous system (CNS), but the underlying signaling mechanisms of regeneration inhibition are not fully understood. Here, we show that suppressing the kinase function of the epidermal growth factor receptor (EGFR) blocks the activities of both myelin inhibitors and chondroitin sulfate proteoglycans in inhibiting neurite outgrowth. In addition, regeneration inhibitors trigger the phosphorylation of EGFR in a calcium-dependent manner. Local administration of EGFR inhibitors promotes significant regeneration of injured optic nerve fibers, pointing to a promising therapeutic avenue for enhancing axon regeneration after CNS injury.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalScience
Volume310
Issue number5745
DOIs
StatePublished - Oct 7 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • General

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    Koprivica, V., Cho, K. S., Park, J. B., Yiu, G. C., Atwal, J., Gore, B., Kim, J. A., Lin, E., Tessier-Lavigne, M., Chen, D. F., & He, Z. (2005). Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science, 310(5745), 106-110. https://doi.org/10.1126/science.1115462