Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

Vuk Koprivica, Kin Sang Cho, Jong Bae Park, Glenn C Yiu, Jasvinder Atwal, Bryan Gore, Jieun A. Kim, Estelle Lin, Marc Tessier-Lavigne, Dong Feng Chen, Zhigang He

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

Inhibitory molecules associated with myelin and the glial scar limit axon regeneration in the adult central nervous system (CNS), but the underlying signaling mechanisms of regeneration inhibition are not fully understood. Here, we show that suppressing the kinase function of the epidermal growth factor receptor (EGFR) blocks the activities of both myelin inhibitors and chondroitin sulfate proteoglycans in inhibiting neurite outgrowth. In addition, regeneration inhibitors trigger the phosphorylation of EGFR in a calcium-dependent manner. Local administration of EGFR inhibitors promotes significant regeneration of injured optic nerve fibers, pointing to a promising therapeutic avenue for enhancing axon regeneration after CNS injury.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalScience
Volume310
Issue number5745
DOIs
StatePublished - Oct 7 2005
Externally publishedYes

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Chondroitin Sulfate Proteoglycans
Neurosciences
Myelin Sheath
Epidermal Growth Factor Receptor
Axons
Regeneration
Central Nervous System
Nervous System Trauma
Optic Nerve
Nerve Fibers
Neuroglia
Cicatrix
Phosphorylation
Calcium

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Neuroscience : EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. / Koprivica, Vuk; Cho, Kin Sang; Park, Jong Bae; Yiu, Glenn C; Atwal, Jasvinder; Gore, Bryan; Kim, Jieun A.; Lin, Estelle; Tessier-Lavigne, Marc; Chen, Dong Feng; He, Zhigang.

In: Science, Vol. 310, No. 5745, 07.10.2005, p. 106-110.

Research output: Contribution to journalArticle

Koprivica, V, Cho, KS, Park, JB, Yiu, GC, Atwal, J, Gore, B, Kim, JA, Lin, E, Tessier-Lavigne, M, Chen, DF & He, Z 2005, 'Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans', Science, vol. 310, no. 5745, pp. 106-110. https://doi.org/10.1126/science.1115462
Koprivica, Vuk ; Cho, Kin Sang ; Park, Jong Bae ; Yiu, Glenn C ; Atwal, Jasvinder ; Gore, Bryan ; Kim, Jieun A. ; Lin, Estelle ; Tessier-Lavigne, Marc ; Chen, Dong Feng ; He, Zhigang. / Neuroscience : EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. In: Science. 2005 ; Vol. 310, No. 5745. pp. 106-110.
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