Abstract
The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1794-1798 |
| Number of pages | 5 |
| Journal | Science |
| Volume | 308 |
| Issue number | 5729 |
| DOIs | |
| State | Published - Jun 17 2005 |
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ASJC Scopus subject areas
- General
Cite this
Neuroscience : Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. / Sun, Tao; Patoine, Christina; Abu-Khalil, Amir; Visvader, Jane; Sum, Eleanor; Cherry, Timothy J.; Orkin, Stuart H.; Geschwind, Daniel H.; Walsh, Christopher A.
In: Science, Vol. 308, No. 5729, 17.06.2005, p. 1794-1798.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuroscience
T2 - Early asymmetry of gene transcription in embryonic human left and right cerebral cortex
AU - Sun, Tao
AU - Patoine, Christina
AU - Abu-Khalil, Amir
AU - Visvader, Jane
AU - Sum, Eleanor
AU - Cherry, Timothy J.
AU - Orkin, Stuart H.
AU - Geschwind, Daniel H.
AU - Walsh, Christopher A.
PY - 2005/6/17
Y1 - 2005/6/17
N2 - The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.
AB - The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.
UR - http://www.scopus.com/inward/record.url?scp=20544435515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20544435515&partnerID=8YFLogxK
U2 - 10.1126/science.1110324
DO - 10.1126/science.1110324
M3 - Article
C2 - 15894532
AN - SCOPUS:20544435515
VL - 308
SP - 1794
EP - 1798
JO - Science
JF - Science
SN - 0036-8075
IS - 5729
ER -