Neuroscience: Early asymmetry of gene transcription in embryonic human left and right cerebral cortex

Tao Sun; Christina Patoine; Amir Abu-Khalil; Jane Visvader; Eleanor Sum; Timothy J. Cherry; Stuart H. Orkin; Daniel H. Geschwind; Christopher A. Walsh

doi:10.1126/science.1110324

Neuroscience: Early asymmetry of gene transcription in embryonic human left and right cerebral cortex

Tao Sun, Christina Patoine, Amir Abu-Khalil, Jane Visvader, Eleanor Sum, Timothy J. Cherry, Stuart H. Orkin, Daniel H. Geschwind, Christopher A. Walsh

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Research output: Contribution to journal › Article › peer-review

271 Scopus citations

Abstract

The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.

Original language	English (US)
Pages (from-to)	1794-1798
Number of pages	5
Journal	Science
Volume	308
Issue number	5729
DOIs	https://doi.org/10.1126/science.1110324
State	Published - Jun 17 2005

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Neuroscience : Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. / Sun, Tao; Patoine, Christina; Abu-Khalil, Amir; Visvader, Jane; Sum, Eleanor; Cherry, Timothy J.; Orkin, Stuart H.; Geschwind, Daniel H.; Walsh, Christopher A.

In: Science, Vol. 308, No. 5729, 17.06.2005, p. 1794-1798.

Research output: Contribution to journal › Article › peer-review

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AU - Geschwind, Daniel H.

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