Neuroscience: Early asymmetry of gene transcription in embryonic human left and right cerebral cortex

Tao Sun, Christina Patoine, Amir Abu-Khalil, Jane Visvader, Eleanor Sum, Timothy J. Cherry, Stuart H. Orkin, Daniel H. Geschwind, Christopher A. Walsh

Research output: Contribution to journalArticle

255 Scopus citations

Abstract

The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentially expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.

Original languageEnglish (US)
Pages (from-to)1794-1798
Number of pages5
JournalScience
Volume308
Issue number5729
DOIs
StatePublished - Jun 17 2005

ASJC Scopus subject areas

  • General

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    Sun, T., Patoine, C., Abu-Khalil, A., Visvader, J., Sum, E., Cherry, T. J., Orkin, S. H., Geschwind, D. H., & Walsh, C. A. (2005). Neuroscience: Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science, 308(5729), 1794-1798. https://doi.org/10.1126/science.1110324