Neuroscience: Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling

Kwan Ng, Jia Da Li, Michelle Y. Cheng, Frances M. Leslie, Alex C. Lee, Qun Yong Zhou

Research output: Contribution to journalArticle

225 Scopus citations

Abstract

Neurogenesis persists in the olfactory bulb (OB) of the adult mammalian brain. New interneurons are continually added to the OB from the subventricularzone (SVZ) via the rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. Within the OB, PK2 may also act as a detachment signal for chain-migrating progenitors arriving from the RMS. PK2 deficiency in mice leads to a marked reduction in OB size, loss of normal OB architecture, and the accumulation of neuronal progenitors in the RMS. These findings define an essential role for G protein-coupled PK2 signaling in postnatal and adult OB neurogenesis.

Original languageEnglish (US)
Pages (from-to)1923-1927
Number of pages5
JournalScience
Volume308
Issue number5730
DOIs
StatePublished - Jun 24 2005
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Ng, K., Li, J. D., Cheng, M. Y., Leslie, F. M., Lee, A. C., & Zhou, Q. Y. (2005). Neuroscience: Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. Science, 308(5730), 1923-1927. https://doi.org/10.1126/science.1112103