Neuroscience and accelerator mass spectrometry

Magnus Palmblad, Bruce A. Buchholz, Darren J. Hillegonds, John S. Vogel

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Accelerator mass spectrometry (AMS) is a mass spectrometric method for quantifying rare isotopes. It has had a great impact in geochronology and archaeology and is now being applied in biomedicine. AMS measures radioisotopes such as 3H, 14C, 26Al, 36Cl and 41Ca, with zepto- or attomole sensitivity and high precision and throughput, allowing safe human pharmacokinetic studies involving microgram doses, agents having low bioavailability or toxicology studies where administered doses must be kept low (<1 μg kg-1). It is used to study long-term pharmacokinetics, to identify biomolecular interactions, to determine chronic and low-dose effects or molecular targets of neurotoxic substances, to quantify transport across the blood-brain barrier and to resolve molecular turnover rates in the human brain on the time-scale of decades. We review here how AMS is applied in neurotoxicology and neuroscience.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalJournal of Mass Spectrometry
Volume40
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

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Keywords

  • Accelerator mass spectrometry
  • Alzheimer's disease
  • Carbon-14
  • Diisopropyl fluorophosphate
  • Radiocarbon

ASJC Scopus subject areas

  • Organic Chemistry
  • Spectroscopy
  • Biophysics

Cite this

Palmblad, M., Buchholz, B. A., Hillegonds, D. J., & Vogel, J. S. (2005). Neuroscience and accelerator mass spectrometry. Journal of Mass Spectrometry, 40(2), 154-159. https://doi.org/10.1002/jms.734