Abstract
The stability of neuropsychological performance in schizophrenia and its relationship to clinical change was contrasted between 60 patients with schizophrenia (30 first-episode, 30 previously treated) and 38 healthy controls using a comprehensive neuropsychological battery and clinical scales administered at intake and at a 19-month follow-up. Consistent with the neurodevelopmental model of schizophrenia, patients demonstrated deficits in cognitive performance at initial testing and did not show decline at follow-up. There were no differences in neuropsychological performance over time between first-episode and previously treated patients, nor between male and female patients or controls. As expected, patients improved clinically with treatment with respect to both positive and negative symptoms. First-episode patients improved more on the positive symptoms of hallucination and delusion; male and female patients showed equivalent clinical improvement. Clinical improvement correlated positively with neuropsychological change, with improved negative symptomatology accounting for most of the significant correlations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-298 |
| Number of pages | 10 |
| Journal | Schizophrenia Research |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 11 1997 |
| Externally published | Yes |
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Keywords
- Neurodevelopment
- Neuropsychology
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia : A longitudinal study. / Censits, David M.; Ragland, John D; Gur, Ruben C.; Gur, Raquel E.
In: Schizophrenia Research, Vol. 24, No. 3, 11.04.1997, p. 289-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia
T2 - A longitudinal study
AU - Censits, David M.
AU - Ragland, John D
AU - Gur, Ruben C.
AU - Gur, Raquel E.
PY - 1997/4/11
Y1 - 1997/4/11
N2 - The stability of neuropsychological performance in schizophrenia and its relationship to clinical change was contrasted between 60 patients with schizophrenia (30 first-episode, 30 previously treated) and 38 healthy controls using a comprehensive neuropsychological battery and clinical scales administered at intake and at a 19-month follow-up. Consistent with the neurodevelopmental model of schizophrenia, patients demonstrated deficits in cognitive performance at initial testing and did not show decline at follow-up. There were no differences in neuropsychological performance over time between first-episode and previously treated patients, nor between male and female patients or controls. As expected, patients improved clinically with treatment with respect to both positive and negative symptoms. First-episode patients improved more on the positive symptoms of hallucination and delusion; male and female patients showed equivalent clinical improvement. Clinical improvement correlated positively with neuropsychological change, with improved negative symptomatology accounting for most of the significant correlations.
AB - The stability of neuropsychological performance in schizophrenia and its relationship to clinical change was contrasted between 60 patients with schizophrenia (30 first-episode, 30 previously treated) and 38 healthy controls using a comprehensive neuropsychological battery and clinical scales administered at intake and at a 19-month follow-up. Consistent with the neurodevelopmental model of schizophrenia, patients demonstrated deficits in cognitive performance at initial testing and did not show decline at follow-up. There were no differences in neuropsychological performance over time between first-episode and previously treated patients, nor between male and female patients or controls. As expected, patients improved clinically with treatment with respect to both positive and negative symptoms. First-episode patients improved more on the positive symptoms of hallucination and delusion; male and female patients showed equivalent clinical improvement. Clinical improvement correlated positively with neuropsychological change, with improved negative symptomatology accounting for most of the significant correlations.
KW - Neurodevelopment
KW - Neuropsychology
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0030980583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030980583&partnerID=8YFLogxK
U2 - 10.1016/S0920-9964(96)00091-6
DO - 10.1016/S0920-9964(96)00091-6
M3 - Article
C2 - 9134589
AN - SCOPUS:0030980583
VL - 24
SP - 289
EP - 298
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 3
ER -