Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: A longitudinal study

David M. Censits, John D Ragland, Ruben C. Gur, Raquel E. Gur

Research output: Contribution to journalArticlepeer-review

256 Scopus citations


The stability of neuropsychological performance in schizophrenia and its relationship to clinical change was contrasted between 60 patients with schizophrenia (30 first-episode, 30 previously treated) and 38 healthy controls using a comprehensive neuropsychological battery and clinical scales administered at intake and at a 19-month follow-up. Consistent with the neurodevelopmental model of schizophrenia, patients demonstrated deficits in cognitive performance at initial testing and did not show decline at follow-up. There were no differences in neuropsychological performance over time between first-episode and previously treated patients, nor between male and female patients or controls. As expected, patients improved clinically with treatment with respect to both positive and negative symptoms. First-episode patients improved more on the positive symptoms of hallucination and delusion; male and female patients showed equivalent clinical improvement. Clinical improvement correlated positively with neuropsychological change, with improved negative symptomatology accounting for most of the significant correlations.

Original languageEnglish (US)
Pages (from-to)289-298
Number of pages10
JournalSchizophrenia Research
Issue number3
StatePublished - Apr 11 1997
Externally publishedYes


  • Neurodevelopment
  • Neuropsychology
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)


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