Neuropsychological differences among empirically derived clinical subtypes of schizophrenia

S. Kristian Hill, John D Ragland, Ruben C. Gur, Raquel E. Gur

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Neuropsychological profile differences between empirically derived clinical subtypes of schizophrenia were examined. Two hundred five patients and 209 demographically matched controls were administered a neuropsychological battery examining 8 domains. Subtypes included negative, disorganized, paranoid, Schneiderian, and mild. All subtypes displayed a neuropsychological profile of generalized impairment with greater deficits in learning, memory, and attention. Results were suggestive of diffuse cognitive dysfunction in schizophrenia with more severe deficits in learning and memory relative to executive skills. This pattern of greater learning and memory impairment was pronounced for disorganized patients. In contrast, paranoid patients outperformed disorganized and negative patients in several domains. These findings reflect bilateral frontal - temporal dysfunction, particularly in disorganized and negative patients. Subtype differences highlight the importance of conceptualizing schizophrenia as a multifocal disorder.

Original languageEnglish (US)
Pages (from-to)492-501
Number of pages10
Issue number4
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology


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