Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patients

K. M. Adams, S. Gilman, R. A. Koeppe, K. J. Kluin, James A Brunberg, D. Dede, S. Berent, P. D. Kroll

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

In an extension of previous work, we studied the behavioral correlates of medial frontal lobe glucose hypometabolism in chronically alcohol-dependent patients. Thirty-one male patients who were detoxified, medically stable, and free of other central nervous system risk factors for neuropsychological impairment were examined with (1) anatomic imaging (CT or MR), (2) functional imaging with [18F] fluorodeoxyglucose (18F-FDG) and positron emission tomography (PET), and (3) a battery of neuropsychological tests, including two measures of abstraction known to be generally sensitive to frontal lobe disease or dysfunction [the Wisconsin Card Sorting Test (WCST) and the Halstead Category Test (HCT)]. 18F-FDG PET data from 18 age- and sex- matched normal control subjects were used for comparison. All patients met criteria for severe alcohol dependence and for at least a mild degree of alcoholic-induced cognitive impairment. Although the mean IQ level of the alcoholic patients was in the average range, the concepts attained and the error scores on the WCST and HCT were significantly impaired in comparison with established norms. Local cerebral metabolic rate for glucose (LCMRglc) was significantly decreased in a sagittal strip of the medial frontal cortex in the alcoholic patients as compared with the normal controls. Comparison of data from PET scans and anatomic images indicated that the reduced LCMRglc could not be attributed to reduced amounts of tissue alone. A statistically significant relationship was found between LCMRglc in the medial frontal region of the cerebral cortex and performance on the WCST, but not the HCT. These findings suggest that chronic alcohol intake results in impaired function of cerebral tissue in the medial frontal region. The impairment pertains both to tissue metabolic rates and the behavioral correlates of these rates.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume17
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

Positron emission tomography
Alcoholics
Positron-Emission Tomography
Sorting
Glucose
Frontal Lobe
Fluorodeoxyglucose F18
Alcohols
Tissue
Imaging techniques
Neurology
Neuropsychological Tests
Cerebral Cortex
Alcoholism
Central Nervous System

Keywords

  • Alcoholism
  • Imaging
  • Neuropsychology
  • Positron Emission Tomography

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patients. / Adams, K. M.; Gilman, S.; Koeppe, R. A.; Kluin, K. J.; Brunberg, James A; Dede, D.; Berent, S.; Kroll, P. D.

In: Alcoholism: Clinical and Experimental Research, Vol. 17, No. 2, 1993, p. 205-210.

Research output: Contribution to journalArticle

Adams, K. M. ; Gilman, S. ; Koeppe, R. A. ; Kluin, K. J. ; Brunberg, James A ; Dede, D. ; Berent, S. ; Kroll, P. D. / Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patients. In: Alcoholism: Clinical and Experimental Research. 1993 ; Vol. 17, No. 2. pp. 205-210.
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