Neuropsychiatric profiles in dementia

David K Johnson, Amber S. Watts, Benjamin A. Chapin, Raeann Anderson, Jeffrey M. Burns

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


We compared patterns of neuropsychiatric symptoms across 4 dementia types [Alzheimer disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB), and Parkinson disease dementia], and 2 mixed groups (AD/VAD and AD/DLB) in sample of 2,963 individuals from the National Alzheimers Coordinating Center Uniform Data Set between September 2005 and June 2008. We used confirmatory factor analysis to compare neuropsychiatric symptom severity ratings made by collateral sources on the Neuropsychiatric Inventory Questionnaire for people with Clinical Dementia Rating scores of 1 or higher. A 3-factor model of psychiatric symptoms (mood, psychotic, and frontal) was shared across all dementia types. Between-group comparisons revealed unique neuropsychiatric profiles by dementia type. The AD group had moderate levels of mood, psychotic, and frontal symptoms whereas VAD exhibited the highest levels and Parkinson disease dementia had the lowest levels. DLB and the mixed dementias had more complex symptom profiles. Depressed mood was the dominant symptom in people with mild diagnoses. Differing psychiatric symptom profiles provide useful information regarding the noncognitive symptoms of dementia.

Original languageEnglish (US)
Pages (from-to)326-332
Number of pages7
JournalAlzheimer Disease and Associated Disorders
Issue number4
StatePublished - Oct 1 2011
Externally publishedYes


  • Alzheimer disease
  • dementia with Lewy bodies
  • mixed dementia
  • Neuropsychiatric symptoms
  • Parkinson disease dementia
  • vascular dementia

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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