Neuropsychiatric features of systemic lupus erythematosus

Andrea T. Borchers, Christopher A. Aoki, Stanley M Naguwa, Carl L Keen, Yehuda Shoenfeld, M. Eric Gershwin

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious and well known complication of systemic lupus erythematosus that remains a significant source of morbidity and mortality. Fortunately, advances in neuroimaging techniques and cognitive testing have improved the diagnosis of this disease and allowed earlier and more successful therapeutic intervention. Further, the association of NPSLE with the anti-phospholipid syndrome, other autoantibodies and inflammatory cytokines have also provided clues to the diagnosis and pathophysiology. Treatment of NPSLE is largely symptom based with outcome based on appropriate diagnosis.

Original languageEnglish (US)
Pages (from-to)329-344
Number of pages16
JournalAutoimmunity Reviews
Issue number6
StatePublished - Jul 2005


  • Anti-phospholipid syndrome
  • Autoantibodies
  • Cognitive testing
  • Cytokines
  • Neuroimaging
  • Neuropsychiatric systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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