Neuroprotection during CPB: From mechanisms to interventions

John M. Murkin, Walter D Boyd, Su Ganapathy, Sandra J. Adams, Rhonda C. Peterson, Joanne Morgan, Peter Lok

Research output: Contribution to journalArticlepeer-review


The incidence and etiology of brain dysfunction after conventional coronary artery bypass surgery using cardiopulmonary bypass are reviewed. Stroke rates and incidences of cognitive dysfunction from various studies are considered. Mechanisms of injury including cerebral embolization as detected by transcranial Doppler and evidence for postoperative cerebral edema are discussed. Evidence for lower overall postoperative morbidity, and for a lower incidence of cognitive dysfunction specifically, after nonpump coronary revascularization is presented.

Original languageEnglish (US)
Pages (from-to)3-6
Number of pages4
JournalSeminars in Cardiothoracic and Vascular Anesthesia
Issue number1
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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