Abstract
A model for studying spinal cord trauma is described using the rat. The neurophysiological parameters that can be monitored in this model include blood pressure, spinal cord blood flow, somatosensory-evoked potentials, electroencephalogram, blood gases, and vital signs. In addition, histological preparations for histochemical fluorescence and neuronal tissue stains can be made from cryostat sections of the cord tissue. Biochemical determinations of the cord tissue are discussed. The rat model is useful because this species is inexpensive and well suited to study the pathophysiology of spinal cord injury. It is a valuable teaching tool in learning basic anesthesiology, physiology, and surgery. The model may also be used to test potentially useful treatments following experimental injury before a larger animal model series is attempted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 356-370 |
| Number of pages | 15 |
| Journal | Experimental Neurology |
| Volume | 70 |
| Issue number | 2 |
| State | Published - 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
Cite this
Neurophysiological recording in rat spinal cord trauma. / De La Torre, J. C.; Boggan, James E.
In: Experimental Neurology, Vol. 70, No. 2, 1980, p. 356-370.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurophysiological recording in rat spinal cord trauma
AU - De La Torre, J. C.
AU - Boggan, James E
PY - 1980
Y1 - 1980
N2 - A model for studying spinal cord trauma is described using the rat. The neurophysiological parameters that can be monitored in this model include blood pressure, spinal cord blood flow, somatosensory-evoked potentials, electroencephalogram, blood gases, and vital signs. In addition, histological preparations for histochemical fluorescence and neuronal tissue stains can be made from cryostat sections of the cord tissue. Biochemical determinations of the cord tissue are discussed. The rat model is useful because this species is inexpensive and well suited to study the pathophysiology of spinal cord injury. It is a valuable teaching tool in learning basic anesthesiology, physiology, and surgery. The model may also be used to test potentially useful treatments following experimental injury before a larger animal model series is attempted.
AB - A model for studying spinal cord trauma is described using the rat. The neurophysiological parameters that can be monitored in this model include blood pressure, spinal cord blood flow, somatosensory-evoked potentials, electroencephalogram, blood gases, and vital signs. In addition, histological preparations for histochemical fluorescence and neuronal tissue stains can be made from cryostat sections of the cord tissue. Biochemical determinations of the cord tissue are discussed. The rat model is useful because this species is inexpensive and well suited to study the pathophysiology of spinal cord injury. It is a valuable teaching tool in learning basic anesthesiology, physiology, and surgery. The model may also be used to test potentially useful treatments following experimental injury before a larger animal model series is attempted.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018943469&partnerID=8YFLogxK
M3 - Article
VL - 70
SP - 356
EP - 370
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -