Neuropharmacological antagonism of the β-carboline-induced 'anxiety' response in rhesus monkeys

Jacqueline Crawley, P. T. Ninan, D. Pickar, G. P. Chrousos, M. Linnoila, P. Skolnick, S. M. Paul

Research output: Contribution to journalArticle

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Abstract

A behavioral and physiological syndrome of stress-related responses was reported in primates following treatment with the benzodiazepine receptor antagonist, β-carboline-3-carboxylic acid ethyl ester (β-CCE). The behavioral and physiological effects of β-CCE are similar to those observed during stressful or 'anxiety'-related conditions characterized in rhesus monkeys under natural conditions. Pharmacological agents which are known to antagonize anxiety responses in other paradigms were tested for their ability to antagonize the actions of β-CCE. Diazepam (1 mg/kg) completely blocked the effects of β-CCE (200 μg/kg) on anxiety-related behaviors, heart rate and blood pressure, plasma catecholamines, cortisol, and adrenocorticotrophic hormone. A presynaptically active dose of the α-adrenoreceptor agonist, clonidine (10 μg/kg), significantly attenuated the effects of β-CCE on all parameters, whereas the β-adrenoreceptor agonist, propranolol (3 mg/kg), failed to alter the increases in plasma catecholamines, cortisol, or ACTH. In addition to these adrenergic agents, the serotonin antagonist, cyproheptadine (1 mg/kg), and the GABA-mimetic 4,5,6,7-tetrahydroisoxazolo(5,4-C)pyrindin-3-ol (1 mg/kg), partially blocked the behavioral, physiological, and biochemical changes after β-CCE. Manifestation of the complete 'anxiety' syndrome evoked by β-CCE in primates may require the functional activity of several neurotransmitter systems.

Original languageEnglish (US)
Pages (from-to)477-485
Number of pages9
JournalJournal of Neuroscience
Volume5
Issue number2
StatePublished - 1985
Externally publishedYes

Fingerprint

Carbolines
Macaca mulatta
Anxiety
Adrenocorticotropic Hormone
Primates
Catecholamines
Hydrocortisone
Cyproheptadine
Serotonin Antagonists
Aptitude
Clonidine
GABA-A Receptors
Diazepam
Propranolol
Adrenergic Agents
gamma-Aminobutyric Acid
Neurotransmitter Agents
Esters
Heart Rate
Pharmacology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Crawley, J., Ninan, P. T., Pickar, D., Chrousos, G. P., Linnoila, M., Skolnick, P., & Paul, S. M. (1985). Neuropharmacological antagonism of the β-carboline-induced 'anxiety' response in rhesus monkeys. Journal of Neuroscience, 5(2), 477-485.

Neuropharmacological antagonism of the β-carboline-induced 'anxiety' response in rhesus monkeys. / Crawley, Jacqueline; Ninan, P. T.; Pickar, D.; Chrousos, G. P.; Linnoila, M.; Skolnick, P.; Paul, S. M.

In: Journal of Neuroscience, Vol. 5, No. 2, 1985, p. 477-485.

Research output: Contribution to journalArticle

Crawley, J, Ninan, PT, Pickar, D, Chrousos, GP, Linnoila, M, Skolnick, P & Paul, SM 1985, 'Neuropharmacological antagonism of the β-carboline-induced 'anxiety' response in rhesus monkeys', Journal of Neuroscience, vol. 5, no. 2, pp. 477-485.
Crawley J, Ninan PT, Pickar D, Chrousos GP, Linnoila M, Skolnick P et al. Neuropharmacological antagonism of the β-carboline-induced 'anxiety' response in rhesus monkeys. Journal of Neuroscience. 1985;5(2):477-485.
Crawley, Jacqueline ; Ninan, P. T. ; Pickar, D. ; Chrousos, G. P. ; Linnoila, M. ; Skolnick, P. ; Paul, S. M. / Neuropharmacological antagonism of the β-carboline-induced 'anxiety' response in rhesus monkeys. In: Journal of Neuroscience. 1985 ; Vol. 5, No. 2. pp. 477-485.
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