Abstract
A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.
Original language | English (US) |
---|---|
Pages (from-to) | 695-699 |
Number of pages | 5 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 15 |
Issue number | 5 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
Keywords
- Antidepressants
- Anxiolytics
- Benzodiazepines
- Exploration
- Locomotion Sedation
- Mouse behavior
- Neuroleptics
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology