Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

Research output: Contribution to journalArticle

410 Citations (Scopus)

Abstract

A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.

Original languageEnglish (US)
Pages (from-to)695-699
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume15
Issue number5
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Benzodiazepines
Animals
Animal Models
Flurazepam
Clorgyline
Meprobamate
Clonazepam
Chlordiazepoxide
Psychotropic Drugs
Chlorpromazine
Diazepam
Pharmacology

Keywords

  • Antidepressants
  • Anxiolytics
  • Benzodiazepines
  • Exploration
  • Locomotion Sedation
  • Mouse behavior
  • Neuroleptics

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

@article{777a242a800c4452a470a53dbcfa8d6d,
title = "Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines",
abstract = "A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.",
keywords = "Antidepressants, Anxiolytics, Benzodiazepines, Exploration, Locomotion Sedation, Mouse behavior, Neuroleptics",
author = "Jacqueline Crawley",
year = "1981",
doi = "10.1016/0091-3057(81)90007-1",
language = "English (US)",
volume = "15",
pages = "695--699",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

AU - Crawley, Jacqueline

PY - 1981

Y1 - 1981

N2 - A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.

AB - A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.

KW - Antidepressants

KW - Anxiolytics

KW - Benzodiazepines

KW - Exploration

KW - Locomotion Sedation

KW - Mouse behavior

KW - Neuroleptics

UR - http://www.scopus.com/inward/record.url?scp=0019823545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019823545&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(81)90007-1

DO - 10.1016/0091-3057(81)90007-1

M3 - Article

C2 - 6118883

AN - SCOPUS:0019823545

VL - 15

SP - 695

EP - 699

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 5

ER -