Abstract
A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 695-699 |
| Number of pages | 5 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
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Keywords
- Antidepressants
- Anxiolytics
- Benzodiazepines
- Exploration
- Locomotion Sedation
- Mouse behavior
- Neuroleptics
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology