Abstract
A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 695-699 |
| Number of pages | 5 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1981 |
| Externally published | Yes |
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Keywords
- Antidepressants
- Anxiolytics
- Benzodiazepines
- Exploration
- Locomotion Sedation
- Mouse behavior
- Neuroleptics
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines. / Crawley, Jacqueline.
In: Pharmacology, Biochemistry and Behavior, Vol. 15, No. 5, 1981, p. 695-699.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines
AU - Crawley, Jacqueline
PY - 1981
Y1 - 1981
N2 - A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.
AB - A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.
KW - Antidepressants
KW - Anxiolytics
KW - Benzodiazepines
KW - Exploration
KW - Locomotion Sedation
KW - Mouse behavior
KW - Neuroleptics
UR - http://www.scopus.com/inward/record.url?scp=0019823545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019823545&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(81)90007-1
DO - 10.1016/0091-3057(81)90007-1
M3 - Article
C2 - 6118883
AN - SCOPUS:0019823545
VL - 15
SP - 695
EP - 699
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 5
ER -