Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

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Abstract

A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.

Original languageEnglish (US)
Pages (from-to)695-699
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume15
Issue number5
DOIs
StatePublished - 1981
Externally publishedYes

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Keywords

  • Antidepressants
  • Anxiolytics
  • Benzodiazepines
  • Exploration
  • Locomotion Sedation
  • Mouse behavior
  • Neuroleptics

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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