Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

Jacqueline Crawley

doi:10.1016/0091-3057(81)90007-1

Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

Jacqueline Crawley

Research output: Contribution to journal › Article › peer-review

437 Scopus citations

Abstract

A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.

Original language	English (US)
Pages (from-to)	695-699
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(81)90007-1
State	Published - 1981
Externally published	Yes

Keywords

Antidepressants
Anxiolytics
Benzodiazepines
Exploration
Locomotion Sedation
Mouse behavior
Neuroleptics

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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10.1016/0091-3057(81)90007-1

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abstract = "A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.",

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AB - A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.

KW - Antidepressants

KW - Anxiolytics

KW - Benzodiazepines

KW - Exploration

KW - Locomotion Sedation

KW - Mouse behavior

KW - Neuroleptics

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Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

Abstract

Keywords

ASJC Scopus subject areas

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