Neuropeptide modulation of social and exploratory behaviors in laboratory rodents

Jacqueline Crawley, S. E. Hays, T. L. O'Donohue, S. M. Paul, F. K. Goodwin

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Neuropeptide influences on exploratory and social behaviors were investigated, using a video-monitored computer-assisted automated animal behavior analysis system. Cholecystokinin decreased exploratory tendencies in the dose range 0.1-5.0 μg/kg IP and 0.5-5.0 μg/IVT, indicating a peripheral mechanism in the CCK reduction of spontaneous behaviors. Neither arginine vasopressin nor alpha-melanocyte stimulating hormone changed parameters of exploratory and social behaviors, strengthening the possibility that their roles in increasing acquisition and retention of operant tasks are specific to neural mechanisms involved in memory and learning. Analysis of spontaneous exploratory and social behavior patterns appears to be a sensitive and effective tool for detecting changes in arousal and attention to environmental stimuli which may underlie more specific behavioral effects of brain neuropeptides.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalPeptides
Volume2
Issue numberSUPPL. 1
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Exploratory Behavior
Social Behavior
Neuropeptides
Rodentia
Modulation
alpha-MSH
Arginine Vasopressin
Cholecystokinin
Brain
Animal Behavior
Animals
Arousal
Data storage equipment
Learning

Keywords

  • Cholecystokinin
  • Exploratory behavior
  • Social behavior
  • Vasopressin
  • α-Melanocyte stimulating hormone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Crawley, J., Hays, S. E., O'Donohue, T. L., Paul, S. M., & Goodwin, F. K. (1981). Neuropeptide modulation of social and exploratory behaviors in laboratory rodents. Peptides, 2(SUPPL. 1), 123-129. https://doi.org/10.1016/0196-9781(81)90066-8

Neuropeptide modulation of social and exploratory behaviors in laboratory rodents. / Crawley, Jacqueline; Hays, S. E.; O'Donohue, T. L.; Paul, S. M.; Goodwin, F. K.

In: Peptides, Vol. 2, No. SUPPL. 1, 1981, p. 123-129.

Research output: Contribution to journalArticle

Crawley, J, Hays, SE, O'Donohue, TL, Paul, SM & Goodwin, FK 1981, 'Neuropeptide modulation of social and exploratory behaviors in laboratory rodents', Peptides, vol. 2, no. SUPPL. 1, pp. 123-129. https://doi.org/10.1016/0196-9781(81)90066-8
Crawley, Jacqueline ; Hays, S. E. ; O'Donohue, T. L. ; Paul, S. M. ; Goodwin, F. K. / Neuropeptide modulation of social and exploratory behaviors in laboratory rodents. In: Peptides. 1981 ; Vol. 2, No. SUPPL. 1. pp. 123-129.
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