Neuropeptide modulation of apomorphine-induced stereotyped behavior

Lisa K. Blumstein, Jacqueline Crawley, Leonard G. Davis, Frank Baldino

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The nucleus accumbens contains many neuropeptides whose functions are presently unknown. The purpose of this study was to determine the extent to which these neuropeptides act in conjuction with the mesolimbic system. Microinjections of cholecystokinin, neurotensin, met-enkephalin, somatostatin, bombesin, as well as glutamate and muscimol, were made into the medial nucleus accumbens after systematic injection of apomorphine. Cholecystokinin and neurotensin, in nanogram doses, potentiated apomorphine-induced stereotypy. Met-enkephalin reduced, whileb somatostatin and bombesin were without effect on, apomorphine-induced stereotypy. In addition, both glutamate and muscimol potentiated this effect. These results that several neuropeptides and amino acids in the nucleus accumbens to modulate apomorphine-induced stereotyped behaviors.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalBrain Research
Volume404
Issue number1-2
DOIs
StatePublished - Feb 24 1987
Externally publishedYes

Keywords

  • Apomorphine
  • Cholecystokinin
  • Dopamine
  • Neurotensin
  • Nucleus accumbens
  • Stereotyped behavior

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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