Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy

D. F. Kelly, G. A.H. Wells, M. Haritani, Robert Higgins, M. Jeffrey

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Central nervous system (CNS) tissues from 192 cats with neurological signs were examined histologically, and tissues from 173 of them were later examined immunohistochemically as part of a survey to determine the prevalence of feline spongiform encephalopathy (FSE). One of the cats was from Norway and the others were from Great Britain. The most commonly recorded clinical signs were ataxia, behavioural changes and epilepsy, but none of the cats had histopathological evidence of FSE. The most common organic CNS lesions were non-suppurative encephalomyelitis in 28 per cent, neoplasia in 15 per cent and a heterogeneous group of degenerative encephalopathies in 9 per cent of the cats. A range of minor histological lesions of uncertain significance was also observed. No histological lesions were observed in the tissues of 63 (33 per cent) of the cats. Disease-specific prion protein (PrPSc) was observed in only one of the 173 cats examined by immunohistochemistry.

Original languageEnglish (US)
Pages (from-to)472-477
Number of pages6
JournalVeterinary Record
Volume156
Issue number15
DOIs
StatePublished - Apr 9 2005
Externally publishedYes

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prion diseases
Felidae
Brain Diseases
Cats
cats
lesions (animal)
Central Nervous System
central nervous system
Encephalomyelitis
Nerve Tissue
Prion Diseases
Ataxia
Norway
PrPSc proteins
encephalopathy
epilepsy
Epilepsy
prions
encephalitis
Immunohistochemistry

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy. / Kelly, D. F.; Wells, G. A.H.; Haritani, M.; Higgins, Robert; Jeffrey, M.

In: Veterinary Record, Vol. 156, No. 15, 09.04.2005, p. 472-477.

Research output: Contribution to journalArticle

Kelly, D. F. ; Wells, G. A.H. ; Haritani, M. ; Higgins, Robert ; Jeffrey, M. / Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy. In: Veterinary Record. 2005 ; Vol. 156, No. 15. pp. 472-477.
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