Abstract
Central nervous system (CNS) tissues from 192 cats with neurological signs were examined histologically, and tissues from 173 of them were later examined immunohistochemically as part of a survey to determine the prevalence of feline spongiform encephalopathy (FSE). One of the cats was from Norway and the others were from Great Britain. The most commonly recorded clinical signs were ataxia, behavioural changes and epilepsy, but none of the cats had histopathological evidence of FSE. The most common organic CNS lesions were non-suppurative encephalomyelitis in 28 per cent, neoplasia in 15 per cent and a heterogeneous group of degenerative encephalopathies in 9 per cent of the cats. A range of minor histological lesions of uncertain significance was also observed. No histological lesions were observed in the tissues of 63 (33 per cent) of the cats. Disease-specific prion protein (PrPSc) was observed in only one of the 173 cats examined by immunohistochemistry.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 472-477 |
| Number of pages | 6 |
| Journal | Veterinary Record |
| Volume | 156 |
| Issue number | 15 |
| DOIs | |
| State | Published - Apr 9 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy. / Kelly, D. F.; Wells, G. A.H.; Haritani, M.; Higgins, Robert; Jeffrey, M.
In: Veterinary Record, Vol. 156, No. 15, 09.04.2005, p. 472-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy
AU - Kelly, D. F.
AU - Wells, G. A.H.
AU - Haritani, M.
AU - Higgins, Robert
AU - Jeffrey, M.
PY - 2005/4/9
Y1 - 2005/4/9
N2 - Central nervous system (CNS) tissues from 192 cats with neurological signs were examined histologically, and tissues from 173 of them were later examined immunohistochemically as part of a survey to determine the prevalence of feline spongiform encephalopathy (FSE). One of the cats was from Norway and the others were from Great Britain. The most commonly recorded clinical signs were ataxia, behavioural changes and epilepsy, but none of the cats had histopathological evidence of FSE. The most common organic CNS lesions were non-suppurative encephalomyelitis in 28 per cent, neoplasia in 15 per cent and a heterogeneous group of degenerative encephalopathies in 9 per cent of the cats. A range of minor histological lesions of uncertain significance was also observed. No histological lesions were observed in the tissues of 63 (33 per cent) of the cats. Disease-specific prion protein (PrPSc) was observed in only one of the 173 cats examined by immunohistochemistry.
AB - Central nervous system (CNS) tissues from 192 cats with neurological signs were examined histologically, and tissues from 173 of them were later examined immunohistochemically as part of a survey to determine the prevalence of feline spongiform encephalopathy (FSE). One of the cats was from Norway and the others were from Great Britain. The most commonly recorded clinical signs were ataxia, behavioural changes and epilepsy, but none of the cats had histopathological evidence of FSE. The most common organic CNS lesions were non-suppurative encephalomyelitis in 28 per cent, neoplasia in 15 per cent and a heterogeneous group of degenerative encephalopathies in 9 per cent of the cats. A range of minor histological lesions of uncertain significance was also observed. No histological lesions were observed in the tissues of 63 (33 per cent) of the cats. Disease-specific prion protein (PrPSc) was observed in only one of the 173 cats examined by immunohistochemistry.
UR - http://www.scopus.com/inward/record.url?scp=17644416427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17644416427&partnerID=8YFLogxK
U2 - 10.1136/vr.156.15.472
DO - 10.1136/vr.156.15.472
M3 - Article
C2 - 15828743
AN - SCOPUS:17644416427
VL - 156
SP - 472
EP - 477
JO - Veterinary Record
JF - Veterinary Record
SN - 0042-4900
IS - 15
ER -