Neuropathogenesis induced by rhesus cytomegalovirus in fetal rhesus monkeys (Macaca mulatta)

Alice F. Tarantal, M. Shahriar Salamat, William J. Britt, Paul A. Luciw, Andrew G. Hendrickx, Peter A. Barry

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Rhesus cytomegalovirus (RhCMV) infection of rhesus macaques offers opportunities to analyze mechanisms of CMV pathogenesis in a primate species. Four fetal rhesus monkeys were inoculated intraperitoneally with RhCMV early in the second trimester, and pregnancies were terminated by hysterotomy during the third trimester. Three fetuses had evidence of severe CMV disease, including intrauterine growth restriction, ventriculomegaly, microcephaly, lissencephaly, and extensive degenerative changes of the cerebral parenchyma. Histopathologic examination revealed polymicrogyria, gliosis, leptomeningitis, periventricular calcifications, and inclusion-bearing cells. These results demonstrate that the developing macaque brain is susceptible to infection with RhCMV early in the second trimester and that intrauterine infection results in neuropathologic outcomes similar to those observed in humans congenitally infected with CMV.

Original languageEnglish (US)
Pages (from-to)446-450
Number of pages5
JournalJournal of Infectious Diseases
Volume177
Issue number2
StatePublished - 1998

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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