The discovery of high concentrations of cholecystokinin octapeptide sulfate (CCK) in the mammalian central nervous system opened a new field of investigation into the functions of this neuropeptide. CCK is synthesized, stored, and released from neurons in the brain. Receptors for CCK, of two distinct pharmacological subtypes, are localized primarily in regions of high CCK concentrations. Excitatory physiological responses to microiontophoretically applied CCK are found at many brain sites. CCK coexists with dopamine in the mesolimbic pathway, and with met-enkephalin in the periaqueductal gray. Functional interactions reported between CCK and dopamine, and between CCK and opiates, have stimulated interest in the possibility that drugs based on CCK analogs and antagonists might provide novel approaches for the development of more efficacious antipsychotics and analgesics, with reduced risks for deleterious side effects.
|Original language||English (US)|
|Number of pages||7|
|Journal||ISI Atlas of Science: Pharmacology|
|State||Published - 1988|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)