Abstract
In a series of multiple regression models predicting either duration or severity of Alzheimer disease (AD) patients, significant linear correlations were found consistently for the volume of CA1, the subiculum, and the entorhinal cortex. Similarly, the total number of neurons in CA1, CA4, and the subiculum was correlated significantly with both the duration and the severity of AD. A hierarchical multiple regression model was used to examine whether any of these intercorrelated measures had any unique relationship to disease duration or severity. The results showed that only CA1 demonstrated a unique contribution to the explained variance in predicting duration or severity of AD for volume and for neuronal numbers. These results indicate that in the hippocampal formation, volume and neuronal numbers of CA1 appear to show a unique relationship with clinical measures of AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 267-269 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 805 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Sep 14 1998 |
| Externally published | Yes |
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Keywords
- Alzheimer disease
- Atrophy
- Clinicopathological correlations
- Hippocampus
- Neuronal loss
- Stereology
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. / Bobinski, Matthew; De Leon, Mony J.; Tarnawski, Michal; Wegiel, Jerzy; Bobinski, Margaret; Reisberg, Barry; Miller, Douglas C.; Wisniewski, Henryk M.
In: Brain Research, Vol. 805, No. 1-2, 14.09.1998, p. 267-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease
AU - Bobinski, Matthew
AU - De Leon, Mony J.
AU - Tarnawski, Michal
AU - Wegiel, Jerzy
AU - Bobinski, Margaret
AU - Reisberg, Barry
AU - Miller, Douglas C.
AU - Wisniewski, Henryk M.
PY - 1998/9/14
Y1 - 1998/9/14
N2 - In a series of multiple regression models predicting either duration or severity of Alzheimer disease (AD) patients, significant linear correlations were found consistently for the volume of CA1, the subiculum, and the entorhinal cortex. Similarly, the total number of neurons in CA1, CA4, and the subiculum was correlated significantly with both the duration and the severity of AD. A hierarchical multiple regression model was used to examine whether any of these intercorrelated measures had any unique relationship to disease duration or severity. The results showed that only CA1 demonstrated a unique contribution to the explained variance in predicting duration or severity of AD for volume and for neuronal numbers. These results indicate that in the hippocampal formation, volume and neuronal numbers of CA1 appear to show a unique relationship with clinical measures of AD.
AB - In a series of multiple regression models predicting either duration or severity of Alzheimer disease (AD) patients, significant linear correlations were found consistently for the volume of CA1, the subiculum, and the entorhinal cortex. Similarly, the total number of neurons in CA1, CA4, and the subiculum was correlated significantly with both the duration and the severity of AD. A hierarchical multiple regression model was used to examine whether any of these intercorrelated measures had any unique relationship to disease duration or severity. The results showed that only CA1 demonstrated a unique contribution to the explained variance in predicting duration or severity of AD for volume and for neuronal numbers. These results indicate that in the hippocampal formation, volume and neuronal numbers of CA1 appear to show a unique relationship with clinical measures of AD.
KW - Alzheimer disease
KW - Atrophy
KW - Clinicopathological correlations
KW - Hippocampus
KW - Neuronal loss
KW - Stereology
UR - http://www.scopus.com/inward/record.url?scp=0032517186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032517186&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(98)00759-8
DO - 10.1016/S0006-8993(98)00759-8
M3 - Article
C2 - 9733982
AN - SCOPUS:0032517186
VL - 805
SP - 267
EP - 269
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -