Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease

Matthew Bobinski, Mony J. De Leon, Michal Tarnawski, Jerzy Wegiel, Margaret Bobinski, Barry Reisberg, Douglas C. Miller, Henryk M. Wisniewski

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

In a series of multiple regression models predicting either duration or severity of Alzheimer disease (AD) patients, significant linear correlations were found consistently for the volume of CA1, the subiculum, and the entorhinal cortex. Similarly, the total number of neurons in CA1, CA4, and the subiculum was correlated significantly with both the duration and the severity of AD. A hierarchical multiple regression model was used to examine whether any of these intercorrelated measures had any unique relationship to disease duration or severity. The results showed that only CA1 demonstrated a unique contribution to the explained variance in predicting duration or severity of AD for volume and for neuronal numbers. These results indicate that in the hippocampal formation, volume and neuronal numbers of CA1 appear to show a unique relationship with clinical measures of AD.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalBrain Research
Volume805
Issue number1-2
DOIs
StatePublished - Sep 14 1998
Externally publishedYes

    Fingerprint

Keywords

  • Alzheimer disease
  • Atrophy
  • Clinicopathological correlations
  • Hippocampus
  • Neuronal loss
  • Stereology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bobinski, M., De Leon, M. J., Tarnawski, M., Wegiel, J., Bobinski, M., Reisberg, B., Miller, D. C., & Wisniewski, H. M. (1998). Neuronal and volume loss in CA1 of the hippocampal formation uniquely predicts duration and severity of Alzheimer disease. Brain Research, 805(1-2), 267-269. https://doi.org/10.1016/S0006-8993(98)00759-8