Neuromuscular transmission as a function of motor unit size in patients with prior poliomyelitis

Ricardo A Maselli, N. R. Cashman, R. L. Wollman, E. F. Salazar-Grueso, R. Roos

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

We studied neuromuscular transmission in 16 patients with prior poliomyelitis by measuring single fiber electromyographic (SFEMG) jitter. This was compared with 3 indirect methods of assessing reinnervation: SFEMG fiber density, macro EMG, and the presence of fiber type grouping on muscle biopsy. In patients with acute poliomyelitis before the age of 10, there was a positive correlation between the extent of neuromuscular transmission impairment, demonstrated by increased SFEMG jitter, and the enlargement of the motor unit, as indicated by increased fiber density, increased macro EMG signals, and fiber type grouping on muscle biopsy. However, there was no correlation between any of these parameters and the presence or absence of new symptoms of weakness. These findings suggest that impaired neuromuscular transmission is most common in patients with prior poliomyelitis whose motor units have been maximally enlarged by axonal sprouting, but is independent of the presence or absence of new symptoms of weakness.

Original languageEnglish (US)
Pages (from-to)648-655
Number of pages8
JournalMuscle and Nerve
Volume15
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

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Keywords

  • macro EMG
  • motor unit
  • neuromuscular transmission
  • poliomyelitis
  • single fiber EMG

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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