Neuromuscular blockade provides no benefit over adequate sedation in ventilated dogs

David M. Steinhorn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To investigate the effect of pharmacological paralysis on systemic oxygen consumption to determine whether pharmacological paralysis offers a physiological benefit over adequate sedation in ventilated animals. Methods: Nine dogs with normal pulmonary function were mechanically ventilated and sedated with α-chloralose while paralysis was induced with vecuronium. Oxygen consumption was determined via indirect calorimeter in each animal repeatedly in the presence or absence of paralysis with seven paired observations in each animal. Sixty-three pairs of data from nine animals were analyzed by analysis of variance with correction for multiple comparisons. Results: Oxygen consumption was 4.3% higher in the unblocked state compared with the blocked state (5.39 ± 0.32 v 5.16 ± 0.34 mL/kg-min, P < .001). Carbon dioxide production was 3.0% higher in the unblocked state compared with the blocked state (4.92 ± 0.24 v 4.77 ± 0.23 mL/kg-min, P < .01). No other physiological effects were noted. Conclusions: Pharmacological paralysis of mechanically ventilated animals with normal pulmonary function that are sedated and resting comfortably produces a statistically significant reduction in oxygen consumption; however, the magnitude of this change is so small that little genuine clinical benefit would be anticipated.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalJournal of Critical Care
Volume10
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

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Neuromuscular Blockade
Paralysis
Oxygen Consumption
Dogs
Pharmacology
Vecuronium Bromide
Lung
Chloralose
Carbon Dioxide
Analysis of Variance

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Neuromuscular blockade provides no benefit over adequate sedation in ventilated dogs. / Steinhorn, David M.

In: Journal of Critical Care, Vol. 10, No. 2, 1995, p. 45-50.

Research output: Contribution to journalArticle

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abstract = "Purpose: To investigate the effect of pharmacological paralysis on systemic oxygen consumption to determine whether pharmacological paralysis offers a physiological benefit over adequate sedation in ventilated animals. Methods: Nine dogs with normal pulmonary function were mechanically ventilated and sedated with α-chloralose while paralysis was induced with vecuronium. Oxygen consumption was determined via indirect calorimeter in each animal repeatedly in the presence or absence of paralysis with seven paired observations in each animal. Sixty-three pairs of data from nine animals were analyzed by analysis of variance with correction for multiple comparisons. Results: Oxygen consumption was 4.3{\%} higher in the unblocked state compared with the blocked state (5.39 ± 0.32 v 5.16 ± 0.34 mL/kg-min, P < .001). Carbon dioxide production was 3.0{\%} higher in the unblocked state compared with the blocked state (4.92 ± 0.24 v 4.77 ± 0.23 mL/kg-min, P < .01). No other physiological effects were noted. Conclusions: Pharmacological paralysis of mechanically ventilated animals with normal pulmonary function that are sedated and resting comfortably produces a statistically significant reduction in oxygen consumption; however, the magnitude of this change is so small that little genuine clinical benefit would be anticipated.",
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