TY - JOUR
T1 - Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults
AU - Dhir, Shibani
AU - Tarasenko, Maya
AU - Napoli, Eleonora
AU - Giulivi, Cecilia R
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others are part of the antioxidant machinery. The brain is highly vulnerable to thiamine deficiency due to its heavy reliance on mitochondrial ATP production. This is more evident during rapid growth (i.e., perinatal periods and children) in which thiamine deficiency is commonly associated with either malnutrition or genetic defects. Thiamine deficiency contributes to a number of conditions spanning from mild neurological and psychiatric symptoms (confusion, reduced memory, and sleep disturbances) to severe encephalopathy, ataxia, congestive heart failure, muscle atrophy, and even death. This review discusses the current knowledge on thiamine deficiency and associated morbidity of neurological and psychiatric disorders, with special emphasis on the pediatric population, as well as the putative beneficial effect of thiamine supplementation in autism spectrum disorder (ASD) and other neurological conditions.
AB - Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others are part of the antioxidant machinery. The brain is highly vulnerable to thiamine deficiency due to its heavy reliance on mitochondrial ATP production. This is more evident during rapid growth (i.e., perinatal periods and children) in which thiamine deficiency is commonly associated with either malnutrition or genetic defects. Thiamine deficiency contributes to a number of conditions spanning from mild neurological and psychiatric symptoms (confusion, reduced memory, and sleep disturbances) to severe encephalopathy, ataxia, congestive heart failure, muscle atrophy, and even death. This review discusses the current knowledge on thiamine deficiency and associated morbidity of neurological and psychiatric disorders, with special emphasis on the pediatric population, as well as the putative beneficial effect of thiamine supplementation in autism spectrum disorder (ASD) and other neurological conditions.
KW - Autism spectrum disorders
KW - Brain
KW - Depressive disorders
KW - Encephalomyopathies
KW - Krebs cycle
KW - Pentose phosphate pathway
KW - Thiamine transporter
UR - http://www.scopus.com/inward/record.url?scp=85068010934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068010934&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2019.00207
DO - 10.3389/fpsyt.2019.00207
M3 - Review article
AN - SCOPUS:85068010934
VL - 10
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
SN - 1664-0640
IS - APR
M1 - 207
ER -