Neurological changes in fruit bats deficient in vitamin B12

Ralph Green, Susan V. Van Tonder, G. Julien Oettle, Gillian Cole, Jack Metz

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

HAEMATOLOGICAL and neurological sequelae are the two major effects of vitamin B12 deficiency in man. In the haemopoietic system, megaloblastic change leading to anaemia seems to be caused by deranged DNA synthesis1. The cause of central nervous system demyelination, however, is unknown and progress in this area has been hampered by the lack of a suitable experimental animal model. We report that Egyptian fruit bats (Rousettus aegyptiacus), made vitamin B12 deficient in captivity, develop neurological changes similar to those observed in human subacute combined degeneration of the spinal cord.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
JournalNature
Volume254
Issue number5496
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Vitamin B 12
Fruit
Subacute Combined Degeneration
Vitamin B 12 Deficiency
Demyelinating Diseases
Anemia
Spinal Cord
Central Nervous System
Animal Models
DNA

ASJC Scopus subject areas

  • General

Cite this

Green, R., Van Tonder, S. V., Oettle, G. J., Cole, G., & Metz, J. (1975). Neurological changes in fruit bats deficient in vitamin B12 Nature, 254(5496), 148-150. https://doi.org/10.1038/254148a0

Neurological changes in fruit bats deficient in vitamin B12 . / Green, Ralph; Van Tonder, Susan V.; Oettle, G. Julien; Cole, Gillian; Metz, Jack.

In: Nature, Vol. 254, No. 5496, 1975, p. 148-150.

Research output: Contribution to journalArticle

Green, R, Van Tonder, SV, Oettle, GJ, Cole, G & Metz, J 1975, 'Neurological changes in fruit bats deficient in vitamin B12 ', Nature, vol. 254, no. 5496, pp. 148-150. https://doi.org/10.1038/254148a0
Green R, Van Tonder SV, Oettle GJ, Cole G, Metz J. Neurological changes in fruit bats deficient in vitamin B12 Nature. 1975;254(5496):148-150. https://doi.org/10.1038/254148a0
Green, Ralph ; Van Tonder, Susan V. ; Oettle, G. Julien ; Cole, Gillian ; Metz, Jack. / Neurological changes in fruit bats deficient in vitamin B12 In: Nature. 1975 ; Vol. 254, No. 5496. pp. 148-150.
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