Neuroinformatics tools for visualizing gene expression in the brain

Floyd E. Bloom; John Morrison; Jeff M. Redwine; John F. Reilly; Warren G. Young

doi:10.1016/S1741-8364(04)02400-X

Neuroinformatics tools for visualizing gene expression in the brain

Floyd E. Bloom, John Morrison, Jeff M. Redwine, John F. Reilly, Warren G. Young

Research output: Contribution to journal › Review article

Abstract

Central nervous system diseases constitute a major target for drug development. Genes expressed by the nervous system may represent half or more of the mammalian genome, with literally tens of thousands of gene products. Better methods are therefore required to accelerate the pace of mapping gene expression patterns in the mouse brain and to evaluate the progressive phenotypic changes in genetic models of human brain diseases. Recent studies of mouse models of amyotrophic lateral sclerosis and Alzheimer's disease illustrate how such data could be used for drug development.

Original language	English (US)
Pages (from-to)	112-119
Number of pages	8
Journal	Drug Discovery Today: BIOSILICO
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/S1741-8364(04)02400-X
State	Published - May 1 2004
Externally published	Yes

ASJC Scopus subject areas

Drug Discovery

Access to Document

10.1016/S1741-8364(04)02400-X

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Bloom, F. E., Morrison, J., Redwine, J. M., Reilly, J. F., & Young, W. G. (2004). Neuroinformatics tools for visualizing gene expression in the brain. Drug Discovery Today: BIOSILICO, 2(3), 112-119. https://doi.org/10.1016/S1741-8364(04)02400-X

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