Abstract
Central nervous system diseases constitute a major target for drug development. Genes expressed by the nervous system may represent half or more of the mammalian genome, with literally tens of thousands of gene products. Better methods are therefore required to accelerate the pace of mapping gene expression patterns in the mouse brain and to evaluate the progressive phenotypic changes in genetic models of human brain diseases. Recent studies of mouse models of amyotrophic lateral sclerosis and Alzheimer's disease illustrate how such data could be used for drug development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 112-119 |
| Number of pages | 8 |
| Journal | Drug Discovery Today: BIOSILICO |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Drug Discovery
Cite this
Neuroinformatics tools for visualizing gene expression in the brain. / Bloom, Floyd E.; Morrison, John; Redwine, Jeff M.; Reilly, John F.; Young, Warren G.
In: Drug Discovery Today: BIOSILICO, Vol. 2, No. 3, 01.05.2004, p. 112-119.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Neuroinformatics tools for visualizing gene expression in the brain
AU - Bloom, Floyd E.
AU - Morrison, John
AU - Redwine, Jeff M.
AU - Reilly, John F.
AU - Young, Warren G.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Central nervous system diseases constitute a major target for drug development. Genes expressed by the nervous system may represent half or more of the mammalian genome, with literally tens of thousands of gene products. Better methods are therefore required to accelerate the pace of mapping gene expression patterns in the mouse brain and to evaluate the progressive phenotypic changes in genetic models of human brain diseases. Recent studies of mouse models of amyotrophic lateral sclerosis and Alzheimer's disease illustrate how such data could be used for drug development.
AB - Central nervous system diseases constitute a major target for drug development. Genes expressed by the nervous system may represent half or more of the mammalian genome, with literally tens of thousands of gene products. Better methods are therefore required to accelerate the pace of mapping gene expression patterns in the mouse brain and to evaluate the progressive phenotypic changes in genetic models of human brain diseases. Recent studies of mouse models of amyotrophic lateral sclerosis and Alzheimer's disease illustrate how such data could be used for drug development.
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UR - http://www.scopus.com/inward/citedby.url?scp=12444314034&partnerID=8YFLogxK
U2 - 10.1016/S1741-8364(04)02400-X
DO - 10.1016/S1741-8364(04)02400-X
M3 - Review article
AN - SCOPUS:12444314034
VL - 2
SP - 112
EP - 119
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 3
ER -