Neuroinformatics: A new tool for studying the brain

Floyd E. Bloom, John Morrison, Warren G. Young

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Background: Central nervous system diseases constitute a major target for drug development. Genes expressed by the nervous system may represent half or more of the mammalian genome, with literally tens of thousands of gene products. Methods: Better methods are therefore required to accelerate the pace of mapping gene expression patterns in the mouse brain and to evaluate the progressive phenotypic changes in genetic models of human brain diseases. Conclusions: Recent studies of mouse models of Amyotrophic Lateral Sclerosis and Alzheimer's disease illustrate how such data could be used for drug development. Since these two diseases - especially Alzheimer's Disease - entail disordered behavior, cognition and emotions, the framework and the methodology described in this article might in the future find applications in research on affective disorders.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Affective Disorders
Volume92
Issue number1
DOIs
StatePublished - May 1 2006
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Cellular pathophysiology
  • Neuroinformatics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

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