Neuroimmune Communication in Health and Disease

Colin Reardon, Kaitlin Murray, Alan E. Lomax

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The immune and nervous systems are tightly integrated, with each system capable of influencing the other to respond to infectious or inflammatory perturbations of homeostasis. Recent studies demonstrating the ability of neural stimulation to significantly reduce the severity of immunopathology and consequently reduce mortality have led to a resurgence in the field of neuroimmunology. Highlighting the tight integration of the nervous and immune systems, afferent neurons can be activated by a diverse range of substances from bacterial-derived products to cytokines released by host cells. While activation of vagal afferents by these substances dominates the literature, additional sensory neurons are responsive as well. It is becoming increasingly clear that although the cholinergic anti-inflammatory pathway has become the predominant model, a multitude of functional circuits exist through which neuronal messengers can influence immunological outcomes. These include pathways whereby efferent signaling occurs independent of the vagus nerve through sympathetic neurons. To receive input from the nervous system, immune cells including B and T cells, macrophages, and professional antigen presenting cells express specific neurotransmitter receptors that affect immune cell function. Specialized immune cell populations not only express neurotransmitter receptors, but express the enzymatic machinery required to produce neurotransmitters, such as acetylcholine, allowing them to act as signaling intermediaries. Although elegant experiments have begun to decipher some of these interactions, integration of these molecules, cells, and anatomy into defined neuroimmune circuits in health and disease is in its infancy. This review describes these circuits and highlights continued challenges and opportunities for the field.

Original languageEnglish (US)
Pages (from-to)2287-2316
Number of pages30
JournalPhysiological Reviews
Volume98
Issue number4
DOIs
StatePublished - Oct 1 2018

Fingerprint

Health Communication
Nervous System
Neurotransmitter Receptor
Immune System
Efferent Pathways
Afferent Neurons
Vagus Nerve
Sensory Receptor Cells
Antigen-Presenting Cells
Cholinergic Agents
Acetylcholine
Neurotransmitter Agents
Anatomy
Homeostasis
B-Lymphocytes
Anti-Inflammatory Agents
Macrophages
Cytokines
T-Lymphocytes
Neurons

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Neuroimmune Communication in Health and Disease. / Reardon, Colin; Murray, Kaitlin; Lomax, Alan E.

In: Physiological Reviews, Vol. 98, No. 4, 01.10.2018, p. 2287-2316.

Research output: Contribution to journalArticle

Reardon, Colin ; Murray, Kaitlin ; Lomax, Alan E. / Neuroimmune Communication in Health and Disease. In: Physiological Reviews. 2018 ; Vol. 98, No. 4. pp. 2287-2316.
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